Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients

M H Platzer; C E H Grattan; Lars K. Poulsen; P S Skov

doi:10.1111/j.1398-9995.2005.00841.x

Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients

M H Platzer, C E H Grattan, Lars K. Poulsen, P S Skov

53 Citations (Scopus)

Abstract

Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (IgE) or the high affinity IgE receptor (FcepsilonRI) and serum-induced histamine release (HR) from basophils and mast cells. We have examined the correlation between the ASST and a new basophil histamine-releasing assay (the HR-Urtikaria test) in a group of well-characterized CU patients and subsequently determined the frequency of HR-Urticaria-positive sera from a larger population of CU patients.

Original language	English
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	60
Issue number	9
Pages (from-to)	1152-6
Number of pages	5
ISSN	0105-4538
DOIs	https://doi.org/10.1111/j.1398-9995.2005.00841.x
Publication status	Published - 2005

Keywords

Adolescent
Adult
Aged
Autoantibodies
Basophils
Child
Child, Preschool
Chronic Disease
Female
Histamine
Humans
Immunoassay
Infant
Infant, Newborn
Male
Middle Aged
Sensitivity and Specificity
Skin Tests
Urticaria

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10.1111/j.1398-9995.2005.00841.x

Cite this

Platzer, M. H., Grattan, C. E. H., Poulsen, L. K., & Skov, P. S. (2005). Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients. Allergy: European Journal of Allergy and Clinical Immunology, 60(9), 1152-6. https://doi.org/10.1111/j.1398-9995.2005.00841.x

Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients. / Platzer, M H; Grattan, C E H; Poulsen, Lars K. et al.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 60, No. 9, 2005, p. 1152-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Platzer, MH, Grattan, CEH, Poulsen, LK & Skov, PS 2005, 'Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients', Allergy: European Journal of Allergy and Clinical Immunology, vol. 60, no. 9, pp. 1152-6. https://doi.org/10.1111/j.1398-9995.2005.00841.x

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title = "Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients",

abstract = "Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (IgE) or the high affinity IgE receptor (FcepsilonRI) and serum-induced histamine release (HR) from basophils and mast cells. We have examined the correlation between the ASST and a new basophil histamine-releasing assay (the HR-Urtikaria test) in a group of well-characterized CU patients and subsequently determined the frequency of HR-Urticaria-positive sera from a larger population of CU patients.",

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AU - Poulsen, Lars K.

AU - Skov, P S

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AB - Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (IgE) or the high affinity IgE receptor (FcepsilonRI) and serum-induced histamine release (HR) from basophils and mast cells. We have examined the correlation between the ASST and a new basophil histamine-releasing assay (the HR-Urtikaria test) in a group of well-characterized CU patients and subsequently determined the frequency of HR-Urticaria-positive sera from a larger population of CU patients.

KW - Adolescent

KW - Adult

KW - Aged

KW - Autoantibodies

KW - Basophils

KW - Child

KW - Child, Preschool

KW - Chronic Disease

KW - Female

KW - Histamine

KW - Humans

KW - Immunoassay

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Middle Aged

KW - Sensitivity and Specificity

KW - Skin Tests

KW - Urticaria

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DO - 10.1111/j.1398-9995.2005.00841.x

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VL - 60

SP - 1152

EP - 1156

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 9

ER -

Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients

Abstract

Keywords

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