Vaccines and multiple sclerosis

TY - JOUR

T1 - Vaccines and multiple sclerosis

AU - Frederiksen, J. L.

AU - Topsøe Mailand, M.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - An association between certain vaccinations and onset or relapse of multiple sclerosis (MS) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis (ON). Case studies were excluded. With the exception of a live vaccine against yellow fever, vaccinations appear safe in untreated patients with MS and ON. However, most studies were underpowered, and small risks cannot be excluded. One study of BCG vaccination after the first demyelinating event showed even a reduced risk of developing MS. Further studies are needed to fully exclude a causal association.

AB - An association between certain vaccinations and onset or relapse of multiple sclerosis (MS) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis (ON). Case studies were excluded. With the exception of a live vaccine against yellow fever, vaccinations appear safe in untreated patients with MS and ON. However, most studies were underpowered, and small risks cannot be excluded. One study of BCG vaccination after the first demyelinating event showed even a reduced risk of developing MS. Further studies are needed to fully exclude a causal association.

KW - multiple sclerosis

KW - optic neuritis

KW - vaccination

UR - http://www.scopus.com/inward/record.url?scp=85032198775&partnerID=8YFLogxK

U2 - 10.1111/ane.12837

DO - 10.1111/ane.12837

M3 - Review

C2 - 29068486

AN - SCOPUS:85032198775

SN - 0065-1427

VL - 136

SP - 49

EP - 51

JO - Acta Neurologica Scandinavica, Supplement

JF - Acta Neurologica Scandinavica, Supplement

IS - S201

ER -