Using Optically Manipulated Metallic Nanoparticles for Cancer Treatment

Kamilla Nørregaard; Jesper Tranekjær Jørgensen; Andreas Kjær; Akbar Samadi; Pól Martin Bendix; Lene Broeng Oddershede

doi:10.1364/OTA.2017.OtTu2E.4

Using Optically Manipulated Metallic Nanoparticles for Cancer Treatment

Kamilla Nørregaard, Jesper Tranekjær Jørgensen, Andreas Kjær, Akbar Samadi, Pól Martin Bendix, Lene Broeng Oddershede

Abstract

A tightly focused laser beam can optically trap individual metallic nanoparticles. While in the trap, the particles will absorb part of the incident light and release this energy in the form of heat into the surroundings. The light-to-heat conversion efficiency of metallic nanoparticles can be quantified by the use of a bio-compatible assay and, if all experimental parameters are known, it can also be theoretically predicted by finite element modeling. Here we present results on optical manipulation and heating properties of a variety of metallic nanoparticles. Also, we demonstrate how they can be used for thermoplasmonic cancer therapy and effectively minimize tumors in living mice.

Original language	English
Title of host publication	Optical Trapping Applications 2017 : Optical Manipulation Applications III (OtTu2E)
Place of Publication	San Diego, California, USA
Publisher	Optical Society of America
Publication date	2 Apr 2017
Article number	OtTuE.4
ISBN (Print)	978-1-943580-25-5
DOIs	https://doi.org/10.1364/OTA.2017.OtTu2E.4
Publication status	Published - 2 Apr 2017

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Using Optically Manipulated Metallic Nanoparticles for Cancer Treatment. / Nørregaard, Kamilla; Jørgensen, Jesper Tranekjær ; Kjær, Andreas et al.

Optical Trapping Applications 2017: Optical Manipulation Applications III (OtTu2E). San Diego, California, USA : Optical Society of America, 2017. OtTuE.4.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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AU - Bendix, Pól Martin

AU - Oddershede, Lene Broeng

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N2 - A tightly focused laser beam can optically trap individual metallic nanoparticles. While in the trap, the particles will absorb part of the incident light and release this energy in the form of heat into the surroundings. The light-to-heat conversion efficiency of metallic nanoparticles can be quantified by the use of a bio-compatible assay and, if all experimental parameters are known, it can also be theoretically predicted by finite element modeling. Here we present results on optical manipulation and heating properties of a variety of metallic nanoparticles. Also, we demonstrate how they can be used for thermoplasmonic cancer therapy and effectively minimize tumors in living mice.

AB - A tightly focused laser beam can optically trap individual metallic nanoparticles. While in the trap, the particles will absorb part of the incident light and release this energy in the form of heat into the surroundings. The light-to-heat conversion efficiency of metallic nanoparticles can be quantified by the use of a bio-compatible assay and, if all experimental parameters are known, it can also be theoretically predicted by finite element modeling. Here we present results on optical manipulation and heating properties of a variety of metallic nanoparticles. Also, we demonstrate how they can be used for thermoplasmonic cancer therapy and effectively minimize tumors in living mice.

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DO - 10.1364/OTA.2017.OtTu2E.4

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BT - Optical Trapping Applications 2017

PB - Optical Society of America

CY - San Diego, California, USA

ER -

Using Optically Manipulated Metallic Nanoparticles for Cancer Treatment

Abstract

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