Using Optically Manipulated Metallic Nanoparticles for Cancer Treatment

TY - GEN

T1 - Using Optically Manipulated Metallic Nanoparticles for Cancer Treatment

AU - Nørregaard, Kamilla

AU - Jørgensen, Jesper Tranekjær

AU - Kjær, Andreas

AU - Samadi, Akbar

AU - Bendix, Pól Martin

AU - Oddershede, Lene Broeng

PY - 2017/4/2

Y1 - 2017/4/2

N2 - A tightly focused laser beam can optically trap individual metallic nanoparticles. While in the trap, the particles will absorb part of the incident light and release this energy in the form of heat into the surroundings. The light-to-heat conversion efficiency of metallic nanoparticles can be quantified by the use of a bio-compatible assay and, if all experimental parameters are known, it can also be theoretically predicted by finite element modeling. Here we present results on optical manipulation and heating properties of a variety of metallic nanoparticles. Also, we demonstrate how they can be used for thermoplasmonic cancer therapy and effectively minimize tumors in living mice.

AB - A tightly focused laser beam can optically trap individual metallic nanoparticles. While in the trap, the particles will absorb part of the incident light and release this energy in the form of heat into the surroundings. The light-to-heat conversion efficiency of metallic nanoparticles can be quantified by the use of a bio-compatible assay and, if all experimental parameters are known, it can also be theoretically predicted by finite element modeling. Here we present results on optical manipulation and heating properties of a variety of metallic nanoparticles. Also, we demonstrate how they can be used for thermoplasmonic cancer therapy and effectively minimize tumors in living mice.

U2 - 10.1364/OTA.2017.OtTu2E.4

DO - 10.1364/OTA.2017.OtTu2E.4

M3 - Article in proceedings

SN - 978-1-943580-25-5

BT - Optical Trapping Applications 2017

PB - Optical Society of America

CY - San Diego, California, USA

ER -