Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

Houshang Amiri; Alexandra de Sitter; Kerstin Bendfeldt; Marco Battaglini; Claudia A M Gandini Wheeler-Kingshott; Massimiliano Calabrese; Jeroen J G Geurts; Maria A Rocca; Jaume Sastre-Garriga; Christian Enzinger; Nicola de Stefano; Massimo Filippi; Álex Rovira; Frederik Barkhof; Hugo Vrenken; MAGNIMS study group; F Barkhof; H Vrenken; O Ciccarelli; J L Fredriksen; J Palace; A Rovira; J Sastre-Garriga

doi:10.1016/j.nicl.2018.04.023

Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

Houshang Amiri, Alexandra de Sitter, Kerstin Bendfeldt, Marco Battaglini, Claudia A M Gandini Wheeler-Kingshott, Massimiliano Calabrese, Jeroen J G Geurts, Maria A Rocca, Jaume Sastre-Garriga, Christian Enzinger, Nicola de Stefano, Massimo Filippi, Álex Rovira, Frederik Barkhof, Hugo Vrenken, MAGNIMS study group, F Barkhof, H Vrenken, O Ciccarelli, J L FredriksenJ Palace, A Rovira, J Sastre-Garriga

Department of Clinical Medicine

22 Citations (Scopus)

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Abstract

Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss the most important challenges currently hampering the measurement and interpretation of GM atrophy in MS. The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care. We discuss the sources and possible solutions of the current challenges, and provide recommendations to achieve reliable measurement and interpretation of brain GM atrophy in MS.

Original language	English
Journal	NeuroImage: Clinical
Volume	19
Pages (from-to)	466-475
ISSN	2213-1582
DOIs	https://doi.org/10.1016/j.nicl.2018.04.023
Publication status	Published - 2018

Keywords

Atrophy/pathology
Brain Mapping
Gray Matter/pathology
Humans
Magnetic Resonance Imaging/methods
Multiple Sclerosis/pathology
White Matter/pathology

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10.1016/j.nicl.2018.04.023Licence: CC BY-NC-ND

1-s2.0-S2213158218301323-mainFinal published version, 1.23 MBLicence: CC BY-NC-ND

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Amiri, H., de Sitter, A., Bendfeldt, K., Battaglini, M., Gandini Wheeler-Kingshott, C. A. M., Calabrese, M., Geurts, J. J. G., Rocca, M. A., Sastre-Garriga, J., Enzinger, C., de Stefano, N., Filippi, M., Rovira, Á., Barkhof, F., Vrenken, H., MAGNIMS study group, Barkhof, F., Vrenken, H., Ciccarelli, O., ... Sastre-Garriga, J. (2018). Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI. NeuroImage: Clinical, 19, 466-475. https://doi.org/10.1016/j.nicl.2018.04.023

Amiri, H, de Sitter, A, Bendfeldt, K, Battaglini, M, Gandini Wheeler-Kingshott, CAM, Calabrese, M, Geurts, JJG, Rocca, MA, Sastre-Garriga, J, Enzinger, C, de Stefano, N, Filippi, M, Rovira, Á, Barkhof, F, Vrenken, H, MAGNIMS study group, Barkhof, F, Vrenken, H, Ciccarelli, O, Fredriksen, JL, Palace, J, Rovira, A & Sastre-Garriga, J 2018, 'Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI', NeuroImage: Clinical, vol. 19, pp. 466-475. https://doi.org/10.1016/j.nicl.2018.04.023

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title = "Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI",

abstract = "Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss the most important challenges currently hampering the measurement and interpretation of GM atrophy in MS. The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care. We discuss the sources and possible solutions of the current challenges, and provide recommendations to achieve reliable measurement and interpretation of brain GM atrophy in MS.",

keywords = "Atrophy/pathology, Brain Mapping, Gray Matter/pathology, Humans, Magnetic Resonance Imaging/methods, Multiple Sclerosis/pathology, White Matter/pathology",

author = "Houshang Amiri and {de Sitter}, Alexandra and Kerstin Bendfeldt and Marco Battaglini and {Gandini Wheeler-Kingshott}, {Claudia A M} and Massimiliano Calabrese and Geurts, {Jeroen J G} and Rocca, {Maria A} and Jaume Sastre-Garriga and Christian Enzinger and {de Stefano}, Nicola and Massimo Filippi and {\'A}lex Rovira and Frederik Barkhof and Hugo Vrenken and {MAGNIMS study group} and F Barkhof and H Vrenken and O Ciccarelli and Fredriksen, {J L} and J Palace and A Rovira and J Sastre-Garriga",

year = "2018",

doi = "10.1016/j.nicl.2018.04.023",

language = "English",

volume = "19",

pages = "466--475",

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T1 - Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

AU - Amiri, Houshang

AU - de Sitter, Alexandra

AU - Bendfeldt, Kerstin

AU - Battaglini, Marco

AU - Gandini Wheeler-Kingshott, Claudia A M

AU - Calabrese, Massimiliano

AU - Geurts, Jeroen J G

AU - Rocca, Maria A

AU - Sastre-Garriga, Jaume

AU - Enzinger, Christian

AU - de Stefano, Nicola

AU - Filippi, Massimo

AU - Rovira, Álex

AU - Barkhof, Frederik

AU - Vrenken, Hugo

AU - MAGNIMS study group

AU - Barkhof, F

AU - Vrenken, H

AU - Ciccarelli, O

AU - Fredriksen, J L

AU - Palace, J

AU - Rovira, A

AU - Sastre-Garriga, J

PY - 2018

Y1 - 2018

N2 - Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss the most important challenges currently hampering the measurement and interpretation of GM atrophy in MS. The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care. We discuss the sources and possible solutions of the current challenges, and provide recommendations to achieve reliable measurement and interpretation of brain GM atrophy in MS.

AB - Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss the most important challenges currently hampering the measurement and interpretation of GM atrophy in MS. The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care. We discuss the sources and possible solutions of the current challenges, and provide recommendations to achieve reliable measurement and interpretation of brain GM atrophy in MS.

KW - Atrophy/pathology

KW - Brain Mapping

KW - Gray Matter/pathology

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Multiple Sclerosis/pathology

KW - White Matter/pathology

U2 - 10.1016/j.nicl.2018.04.023

DO - 10.1016/j.nicl.2018.04.023

M3 - Journal article

C2 - 29984155

SN - 2213-1582

VL - 19

SP - 466

EP - 475

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

ER -

Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

Abstract

Keywords

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