Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways

David Nilsson; Lotta Gustafsson; Angelica Wackenfors; Bodil Gesslein; Lars Edvinsson; Per Paulsson; Richard Ingemansson; Malin Malmsjö

doi:10.1186/1471-2261-8-21

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways

David Nilsson, Lotta Gustafsson, Angelica Wackenfors, Bodil Gesslein, Lars Edvinsson, Per Paulsson, Richard Ingemansson, Malin Malmsjö

Neuronal Signalling

9 Citations (Scopus)

Abstract

Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a suitable method for, ex vivo, in detail delineation of the regulation of endothelin receptors. We hypothesize that mitogen-activated kinases (MAPK) and protein kinase C (PKC) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries.

Original language	English
Journal	B M C Cardiovascular Disorders
Volume	8
Pages (from-to)	21
ISSN	1471-2261
DOIs	https://doi.org/10.1186/1471-2261-8-21
Publication status	Published - 2008

Keywords

Adult
Aged
Aged, 80 and over
Blotting, Western
Dose-Response Relationship, Drug
Endothelin-1
Female
Humans
Male
Mammary Arteries
Middle Aged
Mitogen-Activated Protein Kinases
Protein Kinase C
Protein Kinase Inhibitors
RNA, Messenger
Receptor, Endothelin A
Receptor, Endothelin B
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Tissue Culture Techniques
Up-Regulation
Vasoconstriction
Vasoconstrictor Agents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1471-2261-8-21

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Nilsson, D., Gustafsson, L., Wackenfors, A., Gesslein, B., Edvinsson, L., Paulsson, P., Ingemansson, R., & Malmsjö, M. (2008). Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. B M C Cardiovascular Disorders, 8, 21. https://doi.org/10.1186/1471-2261-8-21

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. / Nilsson, David; Gustafsson, Lotta; Wackenfors, Angelica et al.

In: B M C Cardiovascular Disorders, Vol. 8, 2008, p. 21.

Research output: Contribution to journal › Journal article › Research › peer-review

Nilsson, D, Gustafsson, L, Wackenfors, A, Gesslein, B, Edvinsson, L, Paulsson, P, Ingemansson, R & Malmsjö, M 2008, 'Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways', B M C Cardiovascular Disorders, vol. 8, pp. 21. https://doi.org/10.1186/1471-2261-8-21

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title = "Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways",

abstract = "Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a suitable method for, ex vivo, in detail delineation of the regulation of endothelin receptors. We hypothesize that mitogen-activated kinases (MAPK) and protein kinase C (PKC) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries.",

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AU - Nilsson, David

AU - Gustafsson, Lotta

AU - Wackenfors, Angelica

AU - Gesslein, Bodil

AU - Edvinsson, Lars

AU - Paulsson, Per

AU - Ingemansson, Richard

AU - Malmsjö, Malin

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N2 - Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a suitable method for, ex vivo, in detail delineation of the regulation of endothelin receptors. We hypothesize that mitogen-activated kinases (MAPK) and protein kinase C (PKC) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries.

AB - Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a suitable method for, ex vivo, in detail delineation of the regulation of endothelin receptors. We hypothesize that mitogen-activated kinases (MAPK) and protein kinase C (PKC) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Blotting, Western

KW - Dose-Response Relationship, Drug

KW - Endothelin-1

KW - Female

KW - Humans

KW - Male

KW - Mammary Arteries

KW - Middle Aged

KW - Mitogen-Activated Protein Kinases

KW - Protein Kinase C

KW - Protein Kinase Inhibitors

KW - RNA, Messenger

KW - Receptor, Endothelin A

KW - Receptor, Endothelin B

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Signal Transduction

KW - Tissue Culture Techniques

KW - Up-Regulation

KW - Vasoconstriction

KW - Vasoconstrictor Agents

U2 - 10.1186/1471-2261-8-21

DO - 10.1186/1471-2261-8-21

M3 - Journal article

C2 - 18778461

SN - 1471-2261

VL - 8

SP - 21

JO - B M C Cardiovascular Disorders

JF - B M C Cardiovascular Disorders

ER -

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways

Abstract

Keywords

UN SDGs

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