@article{c04dc8605aa94c1eb2d8e46ed91706c0,
title = "Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways",
abstract = "Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a suitable method for, ex vivo, in detail delineation of the regulation of endothelin receptors. We hypothesize that mitogen-activated kinases (MAPK) and protein kinase C (PKC) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries.",
keywords = "Adult, Aged, Aged, 80 and over, Blotting, Western, Dose-Response Relationship, Drug, Endothelin-1, Female, Humans, Male, Mammary Arteries, Middle Aged, Mitogen-Activated Protein Kinases, Protein Kinase C, Protein Kinase Inhibitors, RNA, Messenger, Receptor, Endothelin A, Receptor, Endothelin B, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Tissue Culture Techniques, Up-Regulation, Vasoconstriction, Vasoconstrictor Agents",
author = "David Nilsson and Lotta Gustafsson and Angelica Wackenfors and Bodil Gesslein and Lars Edvinsson and Per Paulsson and Richard Ingemansson and Malin Malmsj{\"o}",
year = "2008",
doi = "10.1186/1471-2261-8-21",
language = "English",
volume = "8",
pages = "21",
journal = "B M C Cardiovascular Disorders",
issn = "1471-2261",
publisher = "BioMed Central Ltd.",
}
