Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis

Ali Asmar; Lene Simonsen; Birgitte Svolgaard; Jens Bülow

doi:10.1097/RLU.0000000000001452

Unexpected Diffuse ¹⁸F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis

Ali Asmar, Lene Simonsen, Birgitte Svolgaard, Jens Bülow

11 Citations (Scopus)

Abstract

An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to ¹⁸F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of ¹⁸F-NaF was without signs of focal metastasis, the ¹⁸F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of ¹⁸F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.

Original language	English
Journal	Clinical Nuclear Medicine
Volume	42
Issue number	1
Pages (from-to)	68-69
ISSN	0363-9762
DOIs	https://doi.org/10.1097/RLU.0000000000001452
Publication status	Published - 11 Nov 2016

Keywords

Aged, 80 and over
Amyloidosis/diagnostic imaging
Bone and Bones/diagnostic imaging
Calcinosis/diagnostic imaging
Diagnosis, Differential
Fluorine Radioisotopes
Humans
Hypercalcemia/diagnosis
Lung Diseases/diagnostic imaging
Male
Multiple Myeloma/complications
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Prostate-Specific Antigen/blood
Prostatic Neoplasms/blood
Severity of Illness Index
Sodium Fluoride
Tomography, X-Ray Computed

Access to Document

10.1097/RLU.0000000000001452

Cite this

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title = "Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis",

abstract = "An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to 18F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of 18F-NaF was without signs of focal metastasis, the 18F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of 18F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.",

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author = "Ali Asmar and Lene Simonsen and Birgitte Svolgaard and Jens B{\"u}low",

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T1 - Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis

AU - Asmar, Ali

AU - Simonsen, Lene

AU - Svolgaard, Birgitte

AU - Bülow, Jens

PY - 2016/11/11

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N2 - An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to 18F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of 18F-NaF was without signs of focal metastasis, the 18F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of 18F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.

AB - An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to 18F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of 18F-NaF was without signs of focal metastasis, the 18F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of 18F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.

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KW - Humans

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KW - Male

KW - Multiple Myeloma/complications

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KW - Prostatic Neoplasms/blood

KW - Severity of Illness Index

KW - Sodium Fluoride

KW - Tomography, X-Ray Computed

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