TY - JOUR
T1 - Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis
AU - Asmar, Ali
AU - Simonsen, Lene
AU - Svolgaard, Birgitte
AU - Bülow, Jens
PY - 2016/11/11
Y1 - 2016/11/11
N2 - An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to 18F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of 18F-NaF was without signs of focal metastasis, the 18F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of 18F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.
AB - An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to 18F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of 18F-NaF was without signs of focal metastasis, the 18F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of 18F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.
KW - Aged, 80 and over
KW - Amyloidosis/diagnostic imaging
KW - Bone and Bones/diagnostic imaging
KW - Calcinosis/diagnostic imaging
KW - Diagnosis, Differential
KW - Fluorine Radioisotopes
KW - Humans
KW - Hypercalcemia/diagnosis
KW - Lung Diseases/diagnostic imaging
KW - Male
KW - Multiple Myeloma/complications
KW - Positron Emission Tomography Computed Tomography
KW - Positron-Emission Tomography
KW - Prostate-Specific Antigen/blood
KW - Prostatic Neoplasms/blood
KW - Severity of Illness Index
KW - Sodium Fluoride
KW - Tomography, X-Ray Computed
U2 - 10.1097/RLU.0000000000001452
DO - 10.1097/RLU.0000000000001452
M3 - Comment/debate
C2 - 27846001
SN - 0363-9762
VL - 42
SP - 68
EP - 69
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 1
ER -