Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Charlotte Rosenkrantz Bodin; Mikkel Mylius Rasmussen; Ann Tabor; Lena Westbom; Eleonor Tiblad; Charlotte Kvist Ekelund; Camilla Bernt Wulff; Ida Vogel; Olav Bjørn Petersen

doi:10.1155/2018/9203985

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Charlotte Rosenkrantz Bodin, Mikkel Mylius Rasmussen, Ann Tabor, Lena Westbom, Eleonor Tiblad, Charlotte Kvist Ekelund, Camilla Bernt Wulff, Ida Vogel, Olav Bjørn Petersen

Department of Clinical Medicine

10 Citations (Scopus)

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Abstract

Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.

Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.

Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.

Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.

Original language	English
Article number	9203985
Journal	BioMed Research International
Volume	2018
ISSN	1110-7243
DOIs	https://doi.org/10.1155/2018/9203985
Publication status	Published - 2018

Keywords

Adult
Cohort Studies
Denmark/epidemiology
Female
Humans
Incidence
Infant, Newborn
Pregnancy
Pregnancy Outcome/epidemiology
Prenatal Care/methods
Prenatal Diagnosis/methods
Spinal Dysraphism/epidemiology
Sweden/epidemiology
Ultrasonography, Prenatal/methods

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Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to SwedenFinal published version, 1.58 MBLicence: CC BY

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Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden. / Bodin, Charlotte Rosenkrantz; Rasmussen, Mikkel Mylius; Tabor, Ann et al.

In: BioMed Research International, Vol. 2018, 9203985, 2018.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden",

abstract = "Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.",

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author = "Bodin, {Charlotte Rosenkrantz} and Rasmussen, {Mikkel Mylius} and Ann Tabor and Lena Westbom and Eleonor Tiblad and Ekelund, {Charlotte Kvist} and Wulff, {Camilla Bernt} and Ida Vogel and Petersen, {Olav Bj{\o}rn}",

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doi = "10.1155/2018/9203985",

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AU - Bodin, Charlotte Rosenkrantz

AU - Rasmussen, Mikkel Mylius

AU - Tabor, Ann

AU - Westbom, Lena

AU - Tiblad, Eleonor

AU - Ekelund, Charlotte Kvist

AU - Wulff, Camilla Bernt

AU - Vogel, Ida

AU - Petersen, Olav Bjørn

PY - 2018

Y1 - 2018

N2 - Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.

AB - Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.

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KW - Cohort Studies

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KW - Female

KW - Humans

KW - Incidence

KW - Infant, Newborn

KW - Pregnancy

KW - Pregnancy Outcome/epidemiology

KW - Prenatal Care/methods

KW - Prenatal Diagnosis/methods

KW - Spinal Dysraphism/epidemiology

KW - Sweden/epidemiology

KW - Ultrasonography, Prenatal/methods

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DO - 10.1155/2018/9203985

M3 - Journal article

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SN - 2314-6133

VL - 2018

JO - BioMed Research International

JF - BioMed Research International

M1 - 9203985

ER -

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Abstract

Keywords

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