TY - JOUR
T1 - Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden
AU - Bodin, Charlotte Rosenkrantz
AU - Rasmussen, Mikkel Mylius
AU - Tabor, Ann
AU - Westbom, Lena
AU - Tiblad, Eleonor
AU - Ekelund, Charlotte Kvist
AU - Wulff, Camilla Bernt
AU - Vogel, Ida
AU - Petersen, Olav Bjørn
PY - 2018
Y1 - 2018
N2 - Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.
AB - Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.
KW - Adult
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Infant, Newborn
KW - Pregnancy
KW - Pregnancy Outcome/epidemiology
KW - Prenatal Care/methods
KW - Prenatal Diagnosis/methods
KW - Spinal Dysraphism/epidemiology
KW - Sweden/epidemiology
KW - Ultrasonography, Prenatal/methods
U2 - 10.1155/2018/9203985
DO - 10.1155/2018/9203985
M3 - Journal article
C2 - 29487873
SN - 1110-7243
VL - 2018
JO - BioMed Research International
JF - BioMed Research International
M1 - 9203985
ER -