Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

TY - JOUR

T1 - Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

AU - Bodin, Charlotte Rosenkrantz

AU - Rasmussen, Mikkel Mylius

AU - Tabor, Ann

AU - Westbom, Lena

AU - Tiblad, Eleonor

AU - Ekelund, Charlotte Kvist

AU - Wulff, Camilla Bernt

AU - Vogel, Ida

AU - Petersen, Olav Bjørn

PY - 2018

Y1 - 2018

N2 - Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.

AB - Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.

KW - Adult

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Infant, Newborn

KW - Pregnancy

KW - Pregnancy Outcome/epidemiology

KW - Prenatal Care/methods

KW - Prenatal Diagnosis/methods

KW - Spinal Dysraphism/epidemiology

KW - Sweden/epidemiology

KW - Ultrasonography, Prenatal/methods

U2 - 10.1155/2018/9203985

DO - 10.1155/2018/9203985

M3 - Journal article

C2 - 29487873

SN - 2314-6133

VL - 2018

JO - BioMed Research International

JF - BioMed Research International

M1 - 9203985

ER -