Ubiquitin domain proteins in disease

TY - JOUR

T1 - Ubiquitin domain proteins in disease

AU - Klausen, Louise Kjær

AU - Schulze, Andrea

AU - Seeger, Michael

AU - Hartmann-Petersen, Rasmus

N1 - Keywords: Animals; Disease Models, Animal; Gene Targeting; Humans; Nervous System Diseases; Protein Structure, Tertiary; Ubiquitin

PY - 2007

Y1 - 2007

N2 - The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).

AB - The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).

U2 - 10.1186/1471-2091-8-S1-S1

DO - 10.1186/1471-2091-8-S1-S1

M3 - Journal article

C2 - 18047733

SN - 0006-2960

VL - 8

SP - 1

JO - Biochemistry

JF - Biochemistry

IS - 1

ER -