U-turns and regulatory RNAs

T Franch; K Gerdes

doi:10.1016/S1369-5274(00)00069-2

U-turns and regulatory RNAs

54 Citations (Scopus)

Abstract

Conventional antisense RNAs, such as those controlling plasmid replication and maintenance, inhibit the function of their target RNAs rapidly and efficiently Novel findings show that a common Ii-turn loop structure mediates fast RNA pairing in the majority of these RNA controlled systems. Usually, an antisense RNA regulates a single, cognate target RNA only. Recent reports, however, show that antisense RNAs can act as promiscuous regulators that control multiple genes in concert to integrate complex physiological responses in Escherichia coli.

Original language	English
Journal	Current Opinion in Microbiology
Volume	3
Issue number	2
Pages (from-to)	159-164
Number of pages	6
ISSN	1369-5274
DOIs	https://doi.org/10.1016/S1369-5274(00)00069-2
Publication status	Published - 2000
Externally published	Yes

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10.1016/S1369-5274(00)00069-2

Cite this

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title = "U-turns and regulatory RNAs",

abstract = "Conventional antisense RNAs, such as those controlling plasmid replication and maintenance, inhibit the function of their target RNAs rapidly and efficiently Novel findings show that a common Ii-turn loop structure mediates fast RNA pairing in the majority of these RNA controlled systems. Usually, an antisense RNA regulates a single, cognate target RNA only. Recent reports, however, show that antisense RNAs can act as promiscuous regulators that control multiple genes in concert to integrate complex physiological responses in Escherichia coli.",

author = "T Franch and K Gerdes",

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AB - Conventional antisense RNAs, such as those controlling plasmid replication and maintenance, inhibit the function of their target RNAs rapidly and efficiently Novel findings show that a common Ii-turn loop structure mediates fast RNA pairing in the majority of these RNA controlled systems. Usually, an antisense RNA regulates a single, cognate target RNA only. Recent reports, however, show that antisense RNAs can act as promiscuous regulators that control multiple genes in concert to integrate complex physiological responses in Escherichia coli.

U2 - 10.1016/S1369-5274(00)00069-2

DO - 10.1016/S1369-5274(00)00069-2

M3 - Review

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JF - Current Opinion in Microbiology

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