Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

TY - JOUR

T1 - Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

AU - Oketch-Rabah, H A

AU - Lemmich, E

AU - Dossaji, S F

AU - Theander, T G

AU - Olsen, C E

AU - Cornett, C

AU - Kharazmi, A

AU - Christensen, S B

N1 - Keywords: Animals; Antimalarials; Antiprotozoal Agents; Coumarins; Furans; Leishmania major; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Plasmodium falciparum

PY - 1997

Y1 - 1997

N2 - Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.

AB - Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.

U2 - 10.1021/np970030o

DO - 10.1021/np970030o

M3 - Journal article

C2 - 9170288

SN - 0163-3864

VL - 60

SP - 458

EP - 461

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -