@article{465f6ff0a0d911dd86a6000ea68e967b,
title = "Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx",
abstract = "Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.",
author = "Oketch-Rabah, {H A} and E Lemmich and Dossaji, {S F} and Theander, {T G} and Olsen, {C E} and C Cornett and A Kharazmi and Christensen, {S B}",
note = "Keywords: Animals; Antimalarials; Antiprotozoal Agents; Coumarins; Furans; Leishmania major; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Plasmodium falciparum",
year = "1997",
doi = "10.1021/np970030o",
language = "English",
volume = "60",
pages = "458--61",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "5",
}