Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

Sofie J Munk; Steffen Heegaard; Holger Mosbech; Lene H Garvey

doi:10.1016/j.jcrs.2013.02.034

Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

Sofie J Munk, Steffen Heegaard, Holger Mosbech, Lene H Garvey

Eyepath Lab

13 Citations (Scopus)

Abstract

We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Original language	English
Journal	Journal of Cataract & Refractive Surgery
Volume	39
Issue number	6
Pages (from-to)	948-51
Number of pages	4
ISSN	0886-3350
DOIs	https://doi.org/10.1016/j.jcrs.2013.02.034
Publication status	Published - Jun 2013

Keywords

Aged
Anaphylaxis
Cataract Extraction
Drug Hypersensitivity
Humans
Male
Methylcellulose
Ophthalmic Solutions
Recurrence
Skin Tests

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10.1016/j.jcrs.2013.02.034

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title = "Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery",

abstract = "We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.",

keywords = "Aged, Anaphylaxis, Cataract Extraction, Drug Hypersensitivity, Humans, Male, Methylcellulose, Ophthalmic Solutions, Recurrence, Skin Tests",

author = "Munk, {Sofie J} and Steffen Heegaard and Holger Mosbech and Garvey, {Lene H}",

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T1 - Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

AU - Munk, Sofie J

AU - Heegaard, Steffen

AU - Mosbech, Holger

AU - Garvey, Lene H

PY - 2013/6

Y1 - 2013/6

N2 - We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

AB - We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

KW - Aged

KW - Anaphylaxis

KW - Cataract Extraction

KW - Drug Hypersensitivity

KW - Humans

KW - Male

KW - Methylcellulose

KW - Ophthalmic Solutions

KW - Recurrence

KW - Skin Tests

U2 - 10.1016/j.jcrs.2013.02.034

DO - 10.1016/j.jcrs.2013.02.034

M3 - Journal article

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VL - 39

SP - 948

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JO - Journal of Cataract & Refractive Surgery

JF - Journal of Cataract & Refractive Surgery

IS - 6

ER -

Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

Abstract

Keywords

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