Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

TY - JOUR

T1 - Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

AU - Munk, Sofie J

AU - Heegaard, Steffen

AU - Mosbech, Holger

AU - Garvey, Lene H

N1 - Copyright © 2013 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

PY - 2013/6

Y1 - 2013/6

N2 - We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

AB - We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

KW - Aged

KW - Anaphylaxis

KW - Cataract Extraction

KW - Drug Hypersensitivity

KW - Humans

KW - Male

KW - Methylcellulose

KW - Ophthalmic Solutions

KW - Recurrence

KW - Skin Tests

U2 - 10.1016/j.jcrs.2013.02.034

DO - 10.1016/j.jcrs.2013.02.034

M3 - Journal article

C2 - 23571290

SN - 0886-3350

VL - 39

SP - 948

EP - 951

JO - Journal of Cataract & Refractive Surgery

JF - Journal of Cataract & Refractive Surgery

IS - 6

ER -