Turnover of T cells in murine gammaherpesvirus 68-infected mice

TY - JOUR

T1 - Turnover of T cells in murine gammaherpesvirus 68-infected mice

AU - Hamilton-Easton, A M

AU - Christensen, Jan Pravsgaard

AU - Doherty, P C

N1 - Keywords: Animals; Bromodeoxyuridine; CD4-Positive T-Lymphocytes; Cell Division; Female; Gammaherpesvirinae; Herpesviridae Infections; Lymphocyte Activation; Mice; Mice, Inbred C57BL

PY - 1999

Y1 - 1999

N2 - Respiratory challenge of C57BL/6 mice with murine gammaherpesvirus 68 induces proliferation of T lymphocytes early after infection, as evidenced by incorporation of the DNA precursor bromodeoxyuridine. Using pulse-chase analysis, splenic and peripheral blood activated T lymphocytes were found to continue dividing for at least a month after the initial virus challenge. The results are in accord with the idea that T cells are stimulated for a substantial time after the acute, lytic phase of virus infection is resolved.

AB - Respiratory challenge of C57BL/6 mice with murine gammaherpesvirus 68 induces proliferation of T lymphocytes early after infection, as evidenced by incorporation of the DNA precursor bromodeoxyuridine. Using pulse-chase analysis, splenic and peripheral blood activated T lymphocytes were found to continue dividing for at least a month after the initial virus challenge. The results are in accord with the idea that T cells are stimulated for a substantial time after the acute, lytic phase of virus infection is resolved.

M3 - Journal article

C2 - 10438881

SN - 0022-538X

VL - 73

SP - 7866

EP - 7869

JO - Journal of Virology

JF - Journal of Virology

IS - 9

ER -