Trying to remember: immunological B cell memory to malaria

TY - JOUR

T1 - Trying to remember

T2 - immunological B cell memory to malaria

AU - Hviid, Lars

AU - Barfod, Lea

AU - Fowkes, Freya J I

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.

AB - In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.

U2 - 10.1016/j.pt.2014.12.009

DO - 10.1016/j.pt.2014.12.009

M3 - Review

C2 - 25596801

SN - 1471-4922

VL - 31

SP - 89

EP - 94

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 3

ER -