Abstract
GLP-1 (glucagon-like peptide-1) is a peptide hormone secreted from endocrine cells in the intestinal mucosa in response to meals. The major effects of GLP-1 are to increase glucose-induced insulin secretion and reduce glucagon release, but GLP-1 also inhibits gastric emptying rate and reduces appetite and bodyweight in obese subjects. In vivo studies using animal models of type 2 diabetes and in vitro studies using human islet cells have suggested that GLP-1 or GLP-1 analogues are also able to increase beta-cell mass, but in animal models of type 1 diabetes, there is much less evidence for a beta-cell preserving effect. This review summarizes the present knowledge of GLP-1 and its analogues regarding its role as a possible treatment in patients with type 1 diabetes. The studies that address the effect of GLP-1 and GLP-1 analogues on beta-cell mass in both type 2 and type 1 diabetes, as well as the potential of GLP-1 as an adjuvant therapy in islet cell transplantation, will be reviewed. Suggestions for future studies of GLP-1 treatment in type 1 diabetes may include early treatment in order to preserve beta-cell mass and prolong the remission period, but should also take a potential insulin sparing effect and changes in the risk of hypoglycemia into account.
| Original language | English |
|---|---|
| Journal | Current Diabetes Reviews |
| Volume | 5 |
| Issue number | 4 |
| Pages (from-to) | 266-75 |
| Number of pages | 10 |
| ISSN | 1875-6417 |
| Publication status | Published - Nov 2009 |
Keywords
- Animals
- Diabetes Mellitus, Type 1
- Glucagon-Like Peptide 1
- Humans
- Hypoglycemic Agents
- Peptides
- Receptors, Glucagon
- Venoms
