Transcription Restart Establishes Chromatin Accessibility after DNA Replication

Kathleen R Stewart-Morgan; Nazaret Reverón-Gómez; Anja Groth

doi:10.1016/j.molcel.2019.04.033

Transcription Restart Establishes Chromatin Accessibility after DNA Replication

Kathleen R Stewart-Morgan, Nazaret Reverón-Gómez, Anja Groth

11 Citations (Scopus)

Abstract

Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.

Original language	English
Journal	Molecular Cell
Volume	75
Issue number	2
Pages (from-to)	284-297
Number of pages	20
ISSN	1097-2765
DOIs	https://doi.org/10.1016/j.molcel.2019.04.033
Publication status	Published - 25 Jul 2019

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title = "Transcription Restart Establishes Chromatin Accessibility after DNA Replication",

abstract = "Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.",

author = "Stewart-Morgan, {Kathleen R} and Nazaret Rever{\'o}n-G{\'o}mez and Anja Groth",

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AU - Groth, Anja

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AB - Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.

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DO - 10.1016/j.molcel.2019.04.033

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SP - 284

EP - 297

JO - Molecular Cell

JF - Molecular Cell

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Transcription Restart Establishes Chromatin Accessibility after DNA Replication

Abstract

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