Transcription Restart Establishes Chromatin Accessibility after DNA Replication

Kathleen R Stewart-Morgan; Nazaret Reverón-Gómez; Anja Groth

doi:10.1016/j.molcel.2019.04.033

Transcription Restart Establishes Chromatin Accessibility after DNA Replication

Kathleen R Stewart-Morgan, Nazaret Reverón-Gómez, Anja Groth

11 Citationer (Scopus)

Abstract

Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.

Originalsprog	Engelsk
Tidsskrift	Molecular Cell
Vol/bind	75
Udgave nummer	2
Sider (fra-til)	284-297
Antal sider	20
ISSN	1097-2765
DOI	https://doi.org/10.1016/j.molcel.2019.04.033
Status	Udgivet - 25 jul. 2019

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10.1016/j.molcel.2019.04.033

http://www.cell.com/article/S1097276519303521/pdf

Citationsformater

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abstract = "Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.",

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AU - Stewart-Morgan, Kathleen R

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N2 - Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.

AB - Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.

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DO - 10.1016/j.molcel.2019.04.033

M3 - Journal article

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EP - 297

JO - Molecular Cell

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Transcription Restart Establishes Chromatin Accessibility after DNA Replication

Abstract

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