Towards fabrication of 3D printed medical devices to prevent biofilm formation.

Niklas Sandler, Ida Salmela, Adyary Fallarero, Ari Rosling, Mohammad Khajeheian, Ruzica Kolakovic, Natalja Genina, Johan Nyman, Pia Vuorela

    107 Citations (Scopus)

    Abstract

    The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the current study the incorporation of anti-microbial nitrofurantoin in a polymer carrier material and subsequent 3D printing of a model structure, which resulted in an inhibition of biofilm colonization. The approach taken is very promising and can open up new avenues to manufacture functional medical devices in the future.
    Original languageEnglish
    JournalInternational Journal of Pharmaceutics
    Volume459
    Issue number1-2
    Pages (from-to)62-4
    Number of pages3
    ISSN0378-5173
    DOIs
    Publication statusPublished - 1 Jan 2014

    Keywords

    • Anti-Bacterial Agents
    • Anti-Bacterial Agents: administration & dosage
    • Anti-Bacterial Agents: chemistry
    • Anti-Bacterial Agents: pharmacology
    • Attachment Sites, Microbiological
    • Attachment Sites, Microbiological: drug effects
    • Biofilms
    • Biofilms: drug effects
    • Biofilms: growth & development
    • Equipment Design
    • Equipment and Supplies
    • Health Care Sector
    • Indicators and Reagents
    • Microbial Sensitivity Tests
    • Nitrofurantoin
    • Nitrofurantoin: administration & dosage
    • Nitrofurantoin: chemistry
    • Nitrofurantoin: pharmacology
    • Oxazines
    • Oxazines: administration & dosage
    • Oxazines: chemistry
    • Printing
    • Spectrophotometry, Ultraviolet
    • Staphylococcus aureus
    • Staphylococcus aureus: drug effects
    • Xanthenes
    • Xanthenes: administration & dosage
    • Xanthenes: chemistry

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