Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae

Christian Marcus Pedersen; Ignacio Figueroa-Perez; Buko Lindner; Artur J. Ulmer; Ulrich Zähringer; Richard R. Schmidt

doi:10.1002/anie.200906163

Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae

Christian Marcus Pedersen, Ignacio Figueroa-Perez, Buko Lindner, Artur J. Ulmer, Ulrich Zähringer, Richard R. Schmidt

46 Citations (Scopus)

Abstract

"Chemical Equation Preseted" Mixed signals: The glycophospholipid 1, consisting of two cholinylphosphoCalNAc units, two 2-acetamino-4-amino2,4,6- trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated.

Original language	Danish
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	14
Pages (from-to)	2585-2590
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.200906163
Publication status	Published - 29 Mar 2010
Externally published	Yes

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10.1002/anie.200906163

Cite this

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author = "Pedersen, {Christian Marcus} and Ignacio Figueroa-Perez and Buko Lindner and Ulmer, {Artur J.} and Ulrich Z{\"a}hringer and Schmidt, {Richard R.}",

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AU - Pedersen, Christian Marcus

AU - Figueroa-Perez, Ignacio

AU - Lindner, Buko

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AU - Zähringer, Ulrich

AU - Schmidt, Richard R.

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AB - "Chemical Equation Preseted" Mixed signals: The glycophospholipid 1, consisting of two cholinylphosphoCalNAc units, two 2-acetamino-4-amino2,4,6- trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated.

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DO - 10.1002/anie.200906163

M3 - Tidsskriftartikel

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