Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae

Christian Marcus Pedersen; Ignacio Figueroa-Perez; Buko Lindner; Artur J. Ulmer; Ulrich Zähringer; Richard R. Schmidt

doi:10.1002/anie.200906163

Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae

Christian Marcus Pedersen, Ignacio Figueroa-Perez, Buko Lindner, Artur J. Ulmer, Ulrich Zähringer, Richard R. Schmidt

46 Citationer (Scopus)

Abstract

"Chemical Equation Preseted" Mixed signals: The glycophospholipid 1, consisting of two cholinylphosphoCalNAc units, two 2-acetamino-4-amino2,4,6- trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated.

Originalsprog	Dansk
Tidsskrift	Angewandte Chemie - International Edition
Vol/bind	49
Udgave nummer	14
Sider (fra-til)	2585-2590
ISSN	1433-7851
DOI	https://doi.org/10.1002/anie.200906163
Status	Udgivet - 29 mar. 2010
Udgivet eksternt	Ja

Adgang til dokumentet

10.1002/anie.200906163

Citationsformater

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author = "Pedersen, {Christian Marcus} and Ignacio Figueroa-Perez and Buko Lindner and Ulmer, {Artur J.} and Ulrich Z{\"a}hringer and Schmidt, {Richard R.}",

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AU - Pedersen, Christian Marcus

AU - Figueroa-Perez, Ignacio

AU - Lindner, Buko

AU - Ulmer, Artur J.

AU - Zähringer, Ulrich

AU - Schmidt, Richard R.

PY - 2010/3/29

Y1 - 2010/3/29

N2 - "Chemical Equation Preseted" Mixed signals: The glycophospholipid 1, consisting of two cholinylphosphoCalNAc units, two 2-acetamino-4-amino2,4,6- trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated.

AB - "Chemical Equation Preseted" Mixed signals: The glycophospholipid 1, consisting of two cholinylphosphoCalNAc units, two 2-acetamino-4-amino2,4,6- trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated.

U2 - 10.1002/anie.200906163

DO - 10.1002/anie.200906163

M3 - Tidsskriftartikel

SN - 1433-7851

VL - 49

SP - 2585

EP - 2590

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 14

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