Total synthesis of ascididemin via anionic cascade ring closure

Ida Nymann Petersen; François Crestey; Jesper Langgaard Kristensen

doi:10.1039/c2cc34725c

Total synthesis of ascididemin via anionic cascade ring closure

Ida Nymann Petersen, François Crestey, Jesper Langgaard Kristensen

Department of Drug Design and Pharmacology

19 Citations (Scopus)

Abstract

A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

Original language	English
Journal	Chemical Communications
Volume	48
Issue number	72
Pages (from-to)	9092-9094
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c2cc34725c
Publication status	Published - 13 Aug 2012

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title = "Total synthesis of ascididemin via anionic cascade ring closure",

abstract = "A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.",

author = "Petersen, {Ida Nymann} and Fran{\c c}ois Crestey and Kristensen, {Jesper Langgaard}",

year = "2012",

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AU - Petersen, Ida Nymann

AU - Crestey, François

AU - Kristensen, Jesper Langgaard

PY - 2012/8/13

Y1 - 2012/8/13

N2 - A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

AB - A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

U2 - 10.1039/c2cc34725c

DO - 10.1039/c2cc34725c

M3 - Journal article

C2 - 22864261

SN - 1359-7345

VL - 48

SP - 9092

EP - 9094

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Total synthesis of ascididemin via anionic cascade ring closure

Abstract

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