Total synthesis of ascididemin via anionic cascade ring closure

TY - JOUR

T1 - Total synthesis of ascididemin via anionic cascade ring closure

AU - Petersen, Ida Nymann

AU - Crestey, François

AU - Kristensen, Jesper Langgaard

PY - 2012/8/13

Y1 - 2012/8/13

N2 - A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

AB - A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

U2 - 10.1039/c2cc34725c

DO - 10.1039/c2cc34725c

M3 - Journal article

C2 - 22864261

SN - 1359-7345

VL - 48

SP - 9092

EP - 9094

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -