Total and inorganic arsenic in dietary supplements based on herbs, other botanicals and algae-a possible contributor to inorganic arsenic exposure

Rikke Susanne Vingborg Hedegaard; Inge Rokkjær; Jens Jørgen Sloth

doi:10.1007/s00216-013-6835-z

Total and inorganic arsenic in dietary supplements based on herbs, other botanicals and algae-a possible contributor to inorganic arsenic exposure

Rikke Susanne Vingborg Hedegaard, Inge Rokkjær, Jens Jørgen Sloth

Food Chemistry

29 Citations (Scopus)

Abstract

The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0.58 to 5.0 mgkg-1 and 0.03 to 3.2 mgkg-1, respectively, with a ratio between inorganic arsenic and total arsenic ranging between 5 and 100 %. Consumption of the recommended dose of the individual dietary supplement would lead to an exposure to inorganic arsenic within the range of 0.07 to 13 μgday-1. Such exposure from dietary supplements would in worst case constitute 62.4 % of the range of benchmark dose lower confidence limit values (BMDL01 at 0.3 to 8 μg kg bw-1 kg-1 day-1) put down by European Food Safety Authority (EFSA) in 2009, for cancers of the lung, skin and bladder, as well as skin lesions. Hence, the results demonstrate that consumption of certain dietary supplements could contribute significantly to the dietary exposure to inorganic arsenic at levels close to the toxicological limits established by EFSA.

Original language	English
Journal	Analytical and Bioanalytical Chemistry
Volume	405
Issue number	13
Pages (from-to)	4429-4435
Number of pages	7
ISSN	1618-2642
DOIs	https://doi.org/10.1007/s00216-013-6835-z
Publication status	Published - May 2013

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Total and inorganic arsenic in dietary supplements based on herbs, other botanicals and algae-a possible contributor to inorganic arsenic exposure. / Hedegaard, Rikke Susanne Vingborg; Rokkjær, Inge; Sloth, Jens Jørgen.

In: Analytical and Bioanalytical Chemistry, Vol. 405, No. 13, 05.2013, p. 4429-4435.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0.58 to 5.0 mgkg-1 and 0.03 to 3.2 mgkg-1, respectively, with a ratio between inorganic arsenic and total arsenic ranging between 5 and 100 %. Consumption of the recommended dose of the individual dietary supplement would lead to an exposure to inorganic arsenic within the range of 0.07 to 13 μgday-1. Such exposure from dietary supplements would in worst case constitute 62.4 % of the range of benchmark dose lower confidence limit values (BMDL01 at 0.3 to 8 μg kg bw-1 kg-1 day-1) put down by European Food Safety Authority (EFSA) in 2009, for cancers of the lung, skin and bladder, as well as skin lesions. Hence, the results demonstrate that consumption of certain dietary supplements could contribute significantly to the dietary exposure to inorganic arsenic at levels close to the toxicological limits established by EFSA.",

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AU - Hedegaard, Rikke Susanne Vingborg

AU - Rokkjær, Inge

AU - Sloth, Jens Jørgen

PY - 2013/5

Y1 - 2013/5

N2 - The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0.58 to 5.0 mgkg-1 and 0.03 to 3.2 mgkg-1, respectively, with a ratio between inorganic arsenic and total arsenic ranging between 5 and 100 %. Consumption of the recommended dose of the individual dietary supplement would lead to an exposure to inorganic arsenic within the range of 0.07 to 13 μgday-1. Such exposure from dietary supplements would in worst case constitute 62.4 % of the range of benchmark dose lower confidence limit values (BMDL01 at 0.3 to 8 μg kg bw-1 kg-1 day-1) put down by European Food Safety Authority (EFSA) in 2009, for cancers of the lung, skin and bladder, as well as skin lesions. Hence, the results demonstrate that consumption of certain dietary supplements could contribute significantly to the dietary exposure to inorganic arsenic at levels close to the toxicological limits established by EFSA.

AB - The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0.58 to 5.0 mgkg-1 and 0.03 to 3.2 mgkg-1, respectively, with a ratio between inorganic arsenic and total arsenic ranging between 5 and 100 %. Consumption of the recommended dose of the individual dietary supplement would lead to an exposure to inorganic arsenic within the range of 0.07 to 13 μgday-1. Such exposure from dietary supplements would in worst case constitute 62.4 % of the range of benchmark dose lower confidence limit values (BMDL01 at 0.3 to 8 μg kg bw-1 kg-1 day-1) put down by European Food Safety Authority (EFSA) in 2009, for cancers of the lung, skin and bladder, as well as skin lesions. Hence, the results demonstrate that consumption of certain dietary supplements could contribute significantly to the dietary exposure to inorganic arsenic at levels close to the toxicological limits established by EFSA.

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KW - Inorganic arsenic

KW - Speciation analysis

KW - HPLC-ICP-MS

KW - Dietary exposure

U2 - 10.1007/s00216-013-6835-z

DO - 10.1007/s00216-013-6835-z

M3 - Journal article

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ER -

Total and inorganic arsenic in dietary supplements based on herbs, other botanicals and algae-a possible contributor to inorganic arsenic exposure

Abstract

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