TY - JOUR
T1 - To spread or not to spread - chromatin modifications in response to DNA damage
AU - Altmeyer, M.
AU - Lukas, J.
PY - 2013/4
Y1 - 2013/4
N2 - Chromatin modifications in response to DNA damage are vital for genome integrity. Multiple proteins and pathways required to generate specialized chromatin domains around DNA lesions have been identified and the increasing amount of information calls for unifying concepts that would allow us to grasp the ever-increasing complexity. This review aims at contributing to this trend by focusing on feed-forward and feedback mechanisms, which in mammalian cells determine the extent of chromatin modifications after DNA damage. We highlight the emerging notion that the nodal points of these highly dynamic pathways operate in a rate-limiting mode, whose deregulation can disrupt physiological boundaries between damaged and undamaged chromatin, dictate repair pathway choice, and determine the fate of cells exposed to genotoxic stress.
AB - Chromatin modifications in response to DNA damage are vital for genome integrity. Multiple proteins and pathways required to generate specialized chromatin domains around DNA lesions have been identified and the increasing amount of information calls for unifying concepts that would allow us to grasp the ever-increasing complexity. This review aims at contributing to this trend by focusing on feed-forward and feedback mechanisms, which in mammalian cells determine the extent of chromatin modifications after DNA damage. We highlight the emerging notion that the nodal points of these highly dynamic pathways operate in a rate-limiting mode, whose deregulation can disrupt physiological boundaries between damaged and undamaged chromatin, dictate repair pathway choice, and determine the fate of cells exposed to genotoxic stress.
UR - http://www.scopus.com/inward/record.url?scp=84877803084&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2012.11.001
DO - 10.1016/j.gde.2012.11.001
M3 - Journal article
C2 - 23312207
AN - SCOPUS:84877803084
SN - 0959-437X
VL - 23
SP - 156
EP - 165
JO - Current Opinion in Genetics & Development
JF - Current Opinion in Genetics & Development
IS - 2
ER -