Abstract
A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
| Translated title of the contribution | The tissue-specific methylation of human-specific endogenous retroviral long terminal repeats |
|---|---|
| Original language | Russian |
| Journal | Bioorganicheskaya Khimiya |
| Volume | 30 |
| Issue number | 5 |
| Pages (from-to) | 493-8 |
| Number of pages | 6 |
| ISSN | 0132-3423 |
| Publication status | Published - 26 Nov 2004 |
| Externally published | Yes |