Abstract
A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
| Bidragets oversatte titel | The tissue-specific methylation of human-specific endogenous retroviral long terminal repeats |
|---|---|
| Originalsprog | Russisk |
| Tidsskrift | Bioorganicheskaya Khimiya |
| Vol/bind | 30 |
| Udgave nummer | 5 |
| Sider (fra-til) | 493-8 |
| Antal sider | 6 |
| ISSN | 0132-3423 |
| Status | Udgivet - 26 nov. 2004 |
| Udgivet eksternt | Ja |
Emneord
- 3',5'-Cyclic-AMP Phosphodiesterases/genetics
- Cyclic Nucleotide Phosphodiesterases, Type 4
- DNA Methylation
- Deoxyribonuclease HpaII/genetics
- Endogenous Retroviruses/genetics
- Gene Expression Regulation
- Gene Order
- Humans
- Liver/physiology
- Lung/physiology
- Lymph Nodes/physiology
- NADH Dehydrogenase
- Organ Specificity
- Proteins/genetics
- Terminal Repeat Sequences