Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production

TY - JOUR

T1 - Timing is Everything

T2 - PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production

AU - Rewitz, Kim F

AU - O'Connor, Michael B

PY - 2011

Y1 - 2011

N2 - During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.

AB - During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.

U2 - 10.3389/fendo.2011.00108

DO - 10.3389/fendo.2011.00108

M3 - Journal article

C2 - 22649397

SN - 1664-2392

VL - 2

SP - 1

EP - 4

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

ER -