TY - JOUR
T1 - Timing is Everything
T2 - PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
AU - Rewitz, Kim F
AU - O'Connor, Michael B
PY - 2011
Y1 - 2011
N2 - During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.
AB - During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.
U2 - 10.3389/fendo.2011.00108
DO - 10.3389/fendo.2011.00108
M3 - Journal article
C2 - 22649397
SN - 1664-2392
VL - 2
SP - 1
EP - 4
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
ER -