Time trends in the incidence of hysterectomy-corrected overall, type 1 and type 2 endometrial cancer in Denmark 1978-2014

Mette Tuxen Faber; Kirsten Frederiksen; Allan Jensen; Peter Bo Aarslev; Susanne K Kjaer

doi:10.1016/j.ygyno.2017.05.015

Time trends in the incidence of hysterectomy-corrected overall, type 1 and type 2 endometrial cancer in Denmark 1978-2014

Mette Tuxen Faber, Kirsten Frederiksen, Allan Jensen, Peter Bo Aarslev, Susanne K Kjaer

Department of Clinical Medicine

11 Citations (Scopus)

Abstract

Objective To investigate time trends in the incidence of overall, type 1 and type 2 endometrial cancer in Denmark 1978–2014, correcting for hysterectomy. Methods Based on the Danish Cancer Registry and the Danish National Patient Registry we calculated hysterectomy-corrected incidence rates of overall, type 1 and type 2 endometrial cancer. Separate analyses for women < 55 years (defined as pre- and perimenopausal age) and women aged ≥ 55 years (defined as postmenopausal age) and analyses allowing for different time trends before and after the study period midyear 1996 were performed. Log-linear Poisson models were used to estimate annual percentage change (APC) in incidence with 95% confidence intervals (CI). Results The overall incidence of endometrial cancer decreased slightly from 1978 to 1995, but in the last two decades of the study period the incidence has been stable (APC = 0.16; 95% CI: − 0.19; 0.50). In the study period (1978–2014) type 1 endometrial cancer incidence decreased slightly (APC = − 0.67; 95% CI:− 0.83; − 0.52), whereas the incidence of type 2 endometrial cancer increased substantially (APC = 4.85; 95% CI: 4.47; 5.23). The decrease in type 1 endometrial cancer was most pronounced before 1996 in women younger than 55 years (APC = − 2.79; 95% CI: − 3.65; − 1.91), while the largest increase in type 2 endometrial cancer was observed after 1996 (APC = 6.42; 95% CI: 5.72; 7.12). Conclusions Over a period of more than 35 years, the incidence of type 1 endometrial cancer decreased, mainly in pre- and perimenopausal women, while type 2 endometrial cancer incidence increased.

Original language	English
Journal	Gynecologic Oncology
Volume	146
Issue number	2
Pages (from-to)	359-367
ISSN	0090-8258
DOIs	https://doi.org/10.1016/j.ygyno.2017.05.015
Publication status	Published - Aug 2017

Keywords

Adenocarcinoma/classification
Adenocarcinoma, Clear Cell/classification
Age Distribution
Aged
Carcinoma, Endometrioid/classification
Carcinosarcoma/classification
Denmark/epidemiology
Endometrial Neoplasms/classification
Female
Humans
Hysterectomy
Incidence
Middle Aged
Neoplasms, Cystic, Mucinous, and Serous/classification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ygyno.2017.05.015

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@article{5d2d5801d0164723b6f9a5cdd3cd5667,

title = "Time trends in the incidence of hysterectomy-corrected overall, type 1 and type 2 endometrial cancer in Denmark 1978-2014",

abstract = "Objective To investigate time trends in the incidence of overall, type 1 and type 2 endometrial cancer in Denmark 1978–2014, correcting for hysterectomy. Methods Based on the Danish Cancer Registry and the Danish National Patient Registry we calculated hysterectomy-corrected incidence rates of overall, type 1 and type 2 endometrial cancer. Separate analyses for women < 55 years (defined as pre- and perimenopausal age) and women aged ≥ 55 years (defined as postmenopausal age) and analyses allowing for different time trends before and after the study period midyear 1996 were performed. Log-linear Poisson models were used to estimate annual percentage change (APC) in incidence with 95% confidence intervals (CI). Results The overall incidence of endometrial cancer decreased slightly from 1978 to 1995, but in the last two decades of the study period the incidence has been stable (APC = 0.16; 95% CI: − 0.19; 0.50). In the study period (1978–2014) type 1 endometrial cancer incidence decreased slightly (APC = − 0.67; 95% CI:− 0.83; − 0.52), whereas the incidence of type 2 endometrial cancer increased substantially (APC = 4.85; 95% CI: 4.47; 5.23). The decrease in type 1 endometrial cancer was most pronounced before 1996 in women younger than 55 years (APC = − 2.79; 95% CI: − 3.65; − 1.91), while the largest increase in type 2 endometrial cancer was observed after 1996 (APC = 6.42; 95% CI: 5.72; 7.12). Conclusions Over a period of more than 35 years, the incidence of type 1 endometrial cancer decreased, mainly in pre- and perimenopausal women, while type 2 endometrial cancer incidence increased.",

keywords = "Adenocarcinoma/classification, Adenocarcinoma, Clear Cell/classification, Age Distribution, Aged, Carcinoma, Endometrioid/classification, Carcinosarcoma/classification, Denmark/epidemiology, Endometrial Neoplasms/classification, Female, Humans, Hysterectomy, Incidence, Middle Aged, Neoplasms, Cystic, Mucinous, and Serous/classification",

author = "Faber, {Mette Tuxen} and Kirsten Frederiksen and Allan Jensen and Aarslev, {Peter Bo} and Kjaer, {Susanne K}",

year = "2017",

month = aug,

doi = "10.1016/j.ygyno.2017.05.015",

language = "English",

volume = "146",

pages = "359--367",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - Time trends in the incidence of hysterectomy-corrected overall, type 1 and type 2 endometrial cancer in Denmark 1978-2014

AU - Faber, Mette Tuxen

AU - Frederiksen, Kirsten

AU - Jensen, Allan

AU - Aarslev, Peter Bo

AU - Kjaer, Susanne K

PY - 2017/8

Y1 - 2017/8

N2 - Objective To investigate time trends in the incidence of overall, type 1 and type 2 endometrial cancer in Denmark 1978–2014, correcting for hysterectomy. Methods Based on the Danish Cancer Registry and the Danish National Patient Registry we calculated hysterectomy-corrected incidence rates of overall, type 1 and type 2 endometrial cancer. Separate analyses for women < 55 years (defined as pre- and perimenopausal age) and women aged ≥ 55 years (defined as postmenopausal age) and analyses allowing for different time trends before and after the study period midyear 1996 were performed. Log-linear Poisson models were used to estimate annual percentage change (APC) in incidence with 95% confidence intervals (CI). Results The overall incidence of endometrial cancer decreased slightly from 1978 to 1995, but in the last two decades of the study period the incidence has been stable (APC = 0.16; 95% CI: − 0.19; 0.50). In the study period (1978–2014) type 1 endometrial cancer incidence decreased slightly (APC = − 0.67; 95% CI:− 0.83; − 0.52), whereas the incidence of type 2 endometrial cancer increased substantially (APC = 4.85; 95% CI: 4.47; 5.23). The decrease in type 1 endometrial cancer was most pronounced before 1996 in women younger than 55 years (APC = − 2.79; 95% CI: − 3.65; − 1.91), while the largest increase in type 2 endometrial cancer was observed after 1996 (APC = 6.42; 95% CI: 5.72; 7.12). Conclusions Over a period of more than 35 years, the incidence of type 1 endometrial cancer decreased, mainly in pre- and perimenopausal women, while type 2 endometrial cancer incidence increased.

AB - Objective To investigate time trends in the incidence of overall, type 1 and type 2 endometrial cancer in Denmark 1978–2014, correcting for hysterectomy. Methods Based on the Danish Cancer Registry and the Danish National Patient Registry we calculated hysterectomy-corrected incidence rates of overall, type 1 and type 2 endometrial cancer. Separate analyses for women < 55 years (defined as pre- and perimenopausal age) and women aged ≥ 55 years (defined as postmenopausal age) and analyses allowing for different time trends before and after the study period midyear 1996 were performed. Log-linear Poisson models were used to estimate annual percentage change (APC) in incidence with 95% confidence intervals (CI). Results The overall incidence of endometrial cancer decreased slightly from 1978 to 1995, but in the last two decades of the study period the incidence has been stable (APC = 0.16; 95% CI: − 0.19; 0.50). In the study period (1978–2014) type 1 endometrial cancer incidence decreased slightly (APC = − 0.67; 95% CI:− 0.83; − 0.52), whereas the incidence of type 2 endometrial cancer increased substantially (APC = 4.85; 95% CI: 4.47; 5.23). The decrease in type 1 endometrial cancer was most pronounced before 1996 in women younger than 55 years (APC = − 2.79; 95% CI: − 3.65; − 1.91), while the largest increase in type 2 endometrial cancer was observed after 1996 (APC = 6.42; 95% CI: 5.72; 7.12). Conclusions Over a period of more than 35 years, the incidence of type 1 endometrial cancer decreased, mainly in pre- and perimenopausal women, while type 2 endometrial cancer incidence increased.

KW - Adenocarcinoma/classification

KW - Adenocarcinoma, Clear Cell/classification

KW - Age Distribution

KW - Aged

KW - Carcinoma, Endometrioid/classification

KW - Carcinosarcoma/classification

KW - Denmark/epidemiology

KW - Endometrial Neoplasms/classification

KW - Female

KW - Humans

KW - Hysterectomy

KW - Incidence

KW - Middle Aged

KW - Neoplasms, Cystic, Mucinous, and Serous/classification

U2 - 10.1016/j.ygyno.2017.05.015

DO - 10.1016/j.ygyno.2017.05.015

M3 - Journal article

C2 - 28545689

SN - 0090-8258

VL - 146

SP - 359

EP - 367

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 2

ER -

Time trends in the incidence of hysterectomy-corrected overall, type 1 and type 2 endometrial cancer in Denmark 1978-2014

Abstract

Keywords

UN SDGs

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