TY - JOUR
T1 - Time trends in the incidence of hysterectomy-corrected overall, type 1 and type 2 endometrial cancer in Denmark 1978-2014
AU - Faber, Mette Tuxen
AU - Frederiksen, Kirsten
AU - Jensen, Allan
AU - Aarslev, Peter Bo
AU - Kjaer, Susanne K
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - Objective To investigate time trends in the incidence of overall, type 1 and type 2 endometrial cancer in Denmark 1978–2014, correcting for hysterectomy. Methods Based on the Danish Cancer Registry and the Danish National Patient Registry we calculated hysterectomy-corrected incidence rates of overall, type 1 and type 2 endometrial cancer. Separate analyses for women < 55 years (defined as pre- and perimenopausal age) and women aged ≥ 55 years (defined as postmenopausal age) and analyses allowing for different time trends before and after the study period midyear 1996 were performed. Log-linear Poisson models were used to estimate annual percentage change (APC) in incidence with 95% confidence intervals (CI). Results The overall incidence of endometrial cancer decreased slightly from 1978 to 1995, but in the last two decades of the study period the incidence has been stable (APC = 0.16; 95% CI: − 0.19; 0.50). In the study period (1978–2014) type 1 endometrial cancer incidence decreased slightly (APC = − 0.67; 95% CI:− 0.83; − 0.52), whereas the incidence of type 2 endometrial cancer increased substantially (APC = 4.85; 95% CI: 4.47; 5.23). The decrease in type 1 endometrial cancer was most pronounced before 1996 in women younger than 55 years (APC = − 2.79; 95% CI: − 3.65; − 1.91), while the largest increase in type 2 endometrial cancer was observed after 1996 (APC = 6.42; 95% CI: 5.72; 7.12). Conclusions Over a period of more than 35 years, the incidence of type 1 endometrial cancer decreased, mainly in pre- and perimenopausal women, while type 2 endometrial cancer incidence increased.
AB - Objective To investigate time trends in the incidence of overall, type 1 and type 2 endometrial cancer in Denmark 1978–2014, correcting for hysterectomy. Methods Based on the Danish Cancer Registry and the Danish National Patient Registry we calculated hysterectomy-corrected incidence rates of overall, type 1 and type 2 endometrial cancer. Separate analyses for women < 55 years (defined as pre- and perimenopausal age) and women aged ≥ 55 years (defined as postmenopausal age) and analyses allowing for different time trends before and after the study period midyear 1996 were performed. Log-linear Poisson models were used to estimate annual percentage change (APC) in incidence with 95% confidence intervals (CI). Results The overall incidence of endometrial cancer decreased slightly from 1978 to 1995, but in the last two decades of the study period the incidence has been stable (APC = 0.16; 95% CI: − 0.19; 0.50). In the study period (1978–2014) type 1 endometrial cancer incidence decreased slightly (APC = − 0.67; 95% CI:− 0.83; − 0.52), whereas the incidence of type 2 endometrial cancer increased substantially (APC = 4.85; 95% CI: 4.47; 5.23). The decrease in type 1 endometrial cancer was most pronounced before 1996 in women younger than 55 years (APC = − 2.79; 95% CI: − 3.65; − 1.91), while the largest increase in type 2 endometrial cancer was observed after 1996 (APC = 6.42; 95% CI: 5.72; 7.12). Conclusions Over a period of more than 35 years, the incidence of type 1 endometrial cancer decreased, mainly in pre- and perimenopausal women, while type 2 endometrial cancer incidence increased.
KW - Adenocarcinoma/classification
KW - Adenocarcinoma, Clear Cell/classification
KW - Age Distribution
KW - Aged
KW - Carcinoma, Endometrioid/classification
KW - Carcinosarcoma/classification
KW - Denmark/epidemiology
KW - Endometrial Neoplasms/classification
KW - Female
KW - Humans
KW - Hysterectomy
KW - Incidence
KW - Middle Aged
KW - Neoplasms, Cystic, Mucinous, and Serous/classification
U2 - 10.1016/j.ygyno.2017.05.015
DO - 10.1016/j.ygyno.2017.05.015
M3 - Journal article
C2 - 28545689
SN - 0090-8258
VL - 146
SP - 359
EP - 367
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
