Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Anat Milman; Aviram Hochstadt; Antoine Andorin; Jean-Baptiste Gourraud; Frederic Sacher; Philippe Mabo; Sung-Hwan Kim; Giulio Conte; Elena Arbelo; Tsukasa Kamakura; Takeshi Aiba; Carlo Napolitano; Carla Giustetto; Isabelle Denjoy; Jimmy J M Juang; Shingo Maeda; Yoshihide Takahashi; Eran Leshem; Yoav Michowitz; Michael Rahkovich; Camilla H Jespersen; Yanushi D Wijeyeratne; Jean Champagne; Leonardo Calo; Zhengrong Huang; Yuka Mizusawa; Pieter G Postema; Ramon Brugada; Arthur A M Wilde; Gan-Xin Yan; Elijah R Behr; Jacob Tfelt-Hansen; Kenzo Hirao; Christian Veltmann; Antoine Leenhardt; Domenico Corrado; Fiorenzo Gaita; Silvia G Priori; Kengo F Kusano; Masahiko Takagi; Pietro Delise; Josep Brugada; Pedro Brugada; Gi-Byoung Nam; Vincent Probst; Bernard Belhassen

doi:10.1093/europace/euy301

Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Anat Milman, Aviram Hochstadt, Antoine Andorin, Jean-Baptiste Gourraud, Frederic Sacher, Philippe Mabo, Sung-Hwan Kim, Giulio Conte, Elena Arbelo, Tsukasa Kamakura, Takeshi Aiba, Carlo Napolitano, Carla Giustetto, Isabelle Denjoy, Jimmy J M Juang, Shingo Maeda, Yoshihide Takahashi, Eran Leshem, Yoav Michowitz, Michael RahkovichCamilla H Jespersen, Yanushi D Wijeyeratne, Jean Champagne, Leonardo Calo, Zhengrong Huang, Yuka Mizusawa, Pieter G Postema, Ramon Brugada, Arthur A M Wilde, Gan-Xin Yan, Elijah R Behr, Jacob Tfelt-Hansen, Kenzo Hirao, Christian Veltmann, Antoine Leenhardt, Domenico Corrado, Fiorenzo Gaita, Silvia G Priori, Kengo F Kusano, Masahiko Takagi, Pietro Delise, Josep Brugada, Pedro Brugada, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen

Section of Forensic Pathology

5 Citations (Scopus)

Abstract

Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.

Original language	English
Journal	Europace
Volume	21
Issue number	5
Pages (from-to)	796–802
ISSN	1099-5129
DOIs	https://doi.org/10.1093/europace/euy301
Publication status	Published - 1 May 2019

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Milman, A., Hochstadt, A., Andorin, A., Gourraud, J.-B., Sacher, F., Mabo, P., Kim, S.-H., Conte, G., Arbelo, E., Kamakura, T., Aiba, T., Napolitano, C., Giustetto, C., Denjoy, I., Juang, J. J. M., Maeda, S., Takahashi, Y., Leshem, E., Michowitz, Y., ... Belhassen, B. (2019). Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS). Europace, 21(5), 796–802. https://doi.org/10.1093/europace/euy301

Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS). / Milman, Anat; Hochstadt, Aviram; Andorin, Antoine et al.
In: Europace, Vol. 21, No. 5, 01.05.2019, p. 796–802.

Research output: Contribution to journal › Journal article › Research › peer-review

Milman, A, Hochstadt, A, Andorin, A, Gourraud, J-B, Sacher, F, Mabo, P, Kim, S-H, Conte, G, Arbelo, E, Kamakura, T, Aiba, T, Napolitano, C, Giustetto, C, Denjoy, I, Juang, JJM, Maeda, S, Takahashi, Y, Leshem, E, Michowitz, Y, Rahkovich, M, Jespersen, CH, Wijeyeratne, YD, Champagne, J, Calo, L, Huang, Z, Mizusawa, Y, Postema, PG, Brugada, R, Wilde, AAM, Yan, G-X, Behr, ER, Tfelt-Hansen, J, Hirao, K, Veltmann, C, Leenhardt, A, Corrado, D, Gaita, F, Priori, SG, Kusano, KF, Takagi, M, Delise, P, Brugada, J, Brugada, P, Nam, G-B, Probst, V & Belhassen, B 2019, 'Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)', Europace, vol. 21, no. 5, pp. 796–802. https://doi.org/10.1093/europace/euy301

@article{da012c70911d4a77922048dec1495e39,

title = "Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)",

abstract = "Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.",

author = "Anat Milman and Aviram Hochstadt and Antoine Andorin and Jean-Baptiste Gourraud and Frederic Sacher and Philippe Mabo and Sung-Hwan Kim and Giulio Conte and Elena Arbelo and Tsukasa Kamakura and Takeshi Aiba and Carlo Napolitano and Carla Giustetto and Isabelle Denjoy and Juang, {Jimmy J M} and Shingo Maeda and Yoshihide Takahashi and Eran Leshem and Yoav Michowitz and Michael Rahkovich and Jespersen, {Camilla H} and Wijeyeratne, {Yanushi D} and Jean Champagne and Leonardo Calo and Zhengrong Huang and Yuka Mizusawa and Postema, {Pieter G} and Ramon Brugada and Wilde, {Arthur A M} and Gan-Xin Yan and Behr, {Elijah R} and Jacob Tfelt-Hansen and Kenzo Hirao and Christian Veltmann and Antoine Leenhardt and Domenico Corrado and Fiorenzo Gaita and Priori, {Silvia G} and Kusano, {Kengo F} and Masahiko Takagi and Pietro Delise and Josep Brugada and Pedro Brugada and Gi-Byoung Nam and Vincent Probst and Bernard Belhassen",

year = "2019",

month = may,

day = "1",

doi = "10.1093/europace/euy301",

language = "English",

volume = "21",

pages = "796–802",

journal = "Europace",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator

T2 - data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

AU - Milman, Anat

AU - Hochstadt, Aviram

AU - Andorin, Antoine

AU - Gourraud, Jean-Baptiste

AU - Sacher, Frederic

AU - Mabo, Philippe

AU - Kim, Sung-Hwan

AU - Conte, Giulio

AU - Arbelo, Elena

AU - Kamakura, Tsukasa

AU - Aiba, Takeshi

AU - Napolitano, Carlo

AU - Giustetto, Carla

AU - Denjoy, Isabelle

AU - Juang, Jimmy J M

AU - Maeda, Shingo

AU - Takahashi, Yoshihide

AU - Leshem, Eran

AU - Michowitz, Yoav

AU - Rahkovich, Michael

AU - Jespersen, Camilla H

AU - Wijeyeratne, Yanushi D

AU - Champagne, Jean

AU - Calo, Leonardo

AU - Huang, Zhengrong

AU - Mizusawa, Yuka

AU - Postema, Pieter G

AU - Brugada, Ramon

AU - Wilde, Arthur A M

AU - Yan, Gan-Xin

AU - Behr, Elijah R

AU - Tfelt-Hansen, Jacob

AU - Hirao, Kenzo

AU - Veltmann, Christian

AU - Leenhardt, Antoine

AU - Corrado, Domenico

AU - Gaita, Fiorenzo

AU - Priori, Silvia G

AU - Kusano, Kengo F

AU - Takagi, Masahiko

AU - Delise, Pietro

AU - Brugada, Josep

AU - Brugada, Pedro

AU - Nam, Gi-Byoung

AU - Probst, Vincent

AU - Belhassen, Bernard

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.

AB - Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.

U2 - 10.1093/europace/euy301

DO - 10.1093/europace/euy301

M3 - Journal article

C2 - 30590530

SN - 1099-5129

VL - 21

SP - 796

EP - 802

JO - Europace

JF - Europace

IS - 5

ER -

Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

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