Milman, A., Hochstadt, A., Andorin, A., Gourraud, J.-B., Sacher, F., Mabo, P., Kim, S.-H., Conte, G., Arbelo, E., Kamakura, T., Aiba, T., Napolitano, C., Giustetto, C., Denjoy, I., Juang, J. J. M., Maeda, S., Takahashi, Y., Leshem, E., Michowitz, Y., ... Belhassen, B. (2019). Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS). Europace, 21(5), 796–802. https://doi.org/10.1093/europace/euy301
Milman, A, Hochstadt, A, Andorin, A, Gourraud, J-B, Sacher, F, Mabo, P, Kim, S-H, Conte, G, Arbelo, E, Kamakura, T, Aiba, T, Napolitano, C, Giustetto, C, Denjoy, I, Juang, JJM, Maeda, S, Takahashi, Y, Leshem, E, Michowitz, Y, Rahkovich, M, Jespersen, CH, Wijeyeratne, YD, Champagne, J, Calo, L, Huang, Z, Mizusawa, Y, Postema, PG, Brugada, R, Wilde, AAM, Yan, G-X, Behr, ER, Tfelt-Hansen, J, Hirao, K, Veltmann, C, Leenhardt, A, Corrado, D, Gaita, F, Priori, SG, Kusano, KF, Takagi, M, Delise, P, Brugada, J, Brugada, P, Nam, G-B, Probst, V & Belhassen, B 2019, 'Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)', Europace, bind 21, nr. 5, s. 796–802. https://doi.org/10.1093/europace/euy301
@article{da012c70911d4a77922048dec1495e39,
title = "Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)",
abstract = "Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.",
author = "Anat Milman and Aviram Hochstadt and Antoine Andorin and Jean-Baptiste Gourraud and Frederic Sacher and Philippe Mabo and Sung-Hwan Kim and Giulio Conte and Elena Arbelo and Tsukasa Kamakura and Takeshi Aiba and Carlo Napolitano and Carla Giustetto and Isabelle Denjoy and Juang, {Jimmy J M} and Shingo Maeda and Yoshihide Takahashi and Eran Leshem and Yoav Michowitz and Michael Rahkovich and Jespersen, {Camilla H} and Wijeyeratne, {Yanushi D} and Jean Champagne and Leonardo Calo and Zhengrong Huang and Yuka Mizusawa and Postema, {Pieter G} and Ramon Brugada and Wilde, {Arthur A M} and Gan-Xin Yan and Behr, {Elijah R} and Jacob Tfelt-Hansen and Kenzo Hirao and Christian Veltmann and Antoine Leenhardt and Domenico Corrado and Fiorenzo Gaita and Priori, {Silvia G} and Kusano, {Kengo F} and Masahiko Takagi and Pietro Delise and Josep Brugada and Pedro Brugada and Gi-Byoung Nam and Vincent Probst and Bernard Belhassen",
year = "2019",
month = may,
day = "1",
doi = "10.1093/europace/euy301",
language = "English",
volume = "21",
pages = "796–802",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "5",
}
TY - JOUR
T1 - Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator
T2 - data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)
AU - Milman, Anat
AU - Hochstadt, Aviram
AU - Andorin, Antoine
AU - Gourraud, Jean-Baptiste
AU - Sacher, Frederic
AU - Mabo, Philippe
AU - Kim, Sung-Hwan
AU - Conte, Giulio
AU - Arbelo, Elena
AU - Kamakura, Tsukasa
AU - Aiba, Takeshi
AU - Napolitano, Carlo
AU - Giustetto, Carla
AU - Denjoy, Isabelle
AU - Juang, Jimmy J M
AU - Maeda, Shingo
AU - Takahashi, Yoshihide
AU - Leshem, Eran
AU - Michowitz, Yoav
AU - Rahkovich, Michael
AU - Jespersen, Camilla H
AU - Wijeyeratne, Yanushi D
AU - Champagne, Jean
AU - Calo, Leonardo
AU - Huang, Zhengrong
AU - Mizusawa, Yuka
AU - Postema, Pieter G
AU - Brugada, Ramon
AU - Wilde, Arthur A M
AU - Yan, Gan-Xin
AU - Behr, Elijah R
AU - Tfelt-Hansen, Jacob
AU - Hirao, Kenzo
AU - Veltmann, Christian
AU - Leenhardt, Antoine
AU - Corrado, Domenico
AU - Gaita, Fiorenzo
AU - Priori, Silvia G
AU - Kusano, Kengo F
AU - Takagi, Masahiko
AU - Delise, Pietro
AU - Brugada, Josep
AU - Brugada, Pedro
AU - Nam, Gi-Byoung
AU - Probst, Vincent
AU - Belhassen, Bernard
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.
AB - Aims: Data on predictors of time-To-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-To-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-To-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-To-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built. Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.
U2 - 10.1093/europace/euy301
DO - 10.1093/europace/euy301
M3 - Journal article
C2 - 30590530
SN - 1099-5129
VL - 21
SP - 796
EP - 802
JO - Europace
JF - Europace
IS - 5
ER -
