Thermodilution-determined Internal Jugular Venous Flow

Peter Rasmussen; Mario Widmer; Matthias P Hilty; Mike Hug; Henrik Sørensen; Shigehiko Ogoh; Kohei Sato; Niels H Secher; Marco Maggiorini; Carsten Lundby

doi:10.1249/MSS.0000000000001143

Thermodilution-determined Internal Jugular Venous Flow

Peter Rasmussen, Mario Widmer, Matthias P Hilty, Mike Hug, Henrik Sørensen, Shigehiko Ogoh, Kohei Sato, Niels H Secher, Marco Maggiorini, Carsten Lundby

Department of Clinical Medicine

1 Citation (Scopus)

Abstract

Purpose: Cerebral blood flow (CBF) increases ∼20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained. Methods: Introducing retrograde thermodilution, IJV flow was measured in eight healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared with changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA V_mean). Results: Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R² = 0.59, P < 0.0001) and correlated to the ultrasound-derived IJV flow (n = 7; Kendall τ, 0.28; P = 0.036). When subjects stood up, IJV blood flow decreased by 9% ± 13% (mean ± SD) (219 ± 57 to 191 ± 73 mL min^-1; P G 0.0001) and the influence of body position was maintained during exercise (P < 0.0001). Exercise increased both IJV flow and MCA V_mean (P = 0.019 and P = 0.012, respectively) and the two responses were similar (P = 0.50). During hypoxia, however, only MCA V_mean responded with a further increase (P < 0.0001). Conclusions: As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.

Original language	English
Journal	Medicine and Science in Sports and Exercise
Volume	49
Issue number	4
Pages (from-to)	661-668
ISSN	0195-9131
DOIs	https://doi.org/10.1249/MSS.0000000000001143
Publication status	Published - 2017

Keywords

Adult
Cerebrovascular Circulation/physiology
Exercise/physiology
Female
Humans
Hypoxia/physiopathology
Jugular Veins/diagnostic imaging
Male
Middle Cerebral Artery/diagnostic imaging
Posture
Rest
Thermodilution/methods
Ultrasonography, Doppler
Young Adult

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10.1249/MSS.0000000000001143

Cite this

@article{232e890fc6044d64892807bca96d2c42,

title = "Thermodilution-determined Internal Jugular Venous Flow",

abstract = "Purpose: Cerebral blood flow (CBF) increases ∼20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained. Methods: Introducing retrograde thermodilution, IJV flow was measured in eight healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared with changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA Vmean). Results: Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R2 = 0.59, P < 0.0001) and correlated to the ultrasound-derived IJV flow (n = 7; Kendall τ, 0.28; P = 0.036). When subjects stood up, IJV blood flow decreased by 9% ± 13% (mean ± SD) (219 ± 57 to 191 ± 73 mL min-1; P G 0.0001) and the influence of body position was maintained during exercise (P < 0.0001). Exercise increased both IJV flow and MCA Vmean (P = 0.019 and P = 0.012, respectively) and the two responses were similar (P = 0.50). During hypoxia, however, only MCA Vmean responded with a further increase (P < 0.0001). Conclusions: As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.",

keywords = "Adult, Cerebrovascular Circulation/physiology, Exercise/physiology, Female, Humans, Hypoxia/physiopathology, Jugular Veins/diagnostic imaging, Male, Middle Cerebral Artery/diagnostic imaging, Posture, Rest, Thermodilution/methods, Ultrasonography, Doppler, Young Adult",

author = "Peter Rasmussen and Mario Widmer and Hilty, {Matthias P} and Mike Hug and Henrik S{\o}rensen and Shigehiko Ogoh and Kohei Sato and Secher, {Niels H} and Marco Maggiorini and Carsten Lundby",

year = "2017",

doi = "10.1249/MSS.0000000000001143",

language = "English",

volume = "49",

pages = "661--668",

journal = "Medicine and Science in Sports and Exercise",

issn = "0195-9131",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

TY - JOUR

T1 - Thermodilution-determined Internal Jugular Venous Flow

AU - Rasmussen, Peter

AU - Widmer, Mario

AU - Hilty, Matthias P

AU - Hug, Mike

AU - Sørensen, Henrik

AU - Ogoh, Shigehiko

AU - Sato, Kohei

AU - Secher, Niels H

AU - Maggiorini, Marco

AU - Lundby, Carsten

PY - 2017

Y1 - 2017

N2 - Purpose: Cerebral blood flow (CBF) increases ∼20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained. Methods: Introducing retrograde thermodilution, IJV flow was measured in eight healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared with changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA Vmean). Results: Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R2 = 0.59, P < 0.0001) and correlated to the ultrasound-derived IJV flow (n = 7; Kendall τ, 0.28; P = 0.036). When subjects stood up, IJV blood flow decreased by 9% ± 13% (mean ± SD) (219 ± 57 to 191 ± 73 mL min-1; P G 0.0001) and the influence of body position was maintained during exercise (P < 0.0001). Exercise increased both IJV flow and MCA Vmean (P = 0.019 and P = 0.012, respectively) and the two responses were similar (P = 0.50). During hypoxia, however, only MCA Vmean responded with a further increase (P < 0.0001). Conclusions: As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.

AB - Purpose: Cerebral blood flow (CBF) increases ∼20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained. Methods: Introducing retrograde thermodilution, IJV flow was measured in eight healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared with changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA Vmean). Results: Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R2 = 0.59, P < 0.0001) and correlated to the ultrasound-derived IJV flow (n = 7; Kendall τ, 0.28; P = 0.036). When subjects stood up, IJV blood flow decreased by 9% ± 13% (mean ± SD) (219 ± 57 to 191 ± 73 mL min-1; P G 0.0001) and the influence of body position was maintained during exercise (P < 0.0001). Exercise increased both IJV flow and MCA Vmean (P = 0.019 and P = 0.012, respectively) and the two responses were similar (P = 0.50). During hypoxia, however, only MCA Vmean responded with a further increase (P < 0.0001). Conclusions: As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.

KW - Adult

KW - Cerebrovascular Circulation/physiology

KW - Exercise/physiology

KW - Female

KW - Humans

KW - Hypoxia/physiopathology

KW - Jugular Veins/diagnostic imaging

KW - Male

KW - Middle Cerebral Artery/diagnostic imaging

KW - Posture

KW - Rest

KW - Thermodilution/methods

KW - Ultrasonography, Doppler

KW - Young Adult

U2 - 10.1249/MSS.0000000000001143

DO - 10.1249/MSS.0000000000001143

M3 - Journal article

C2 - 27861273

SN - 0195-9131

VL - 49

SP - 661

EP - 668

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 4

ER -

Thermodilution-determined Internal Jugular Venous Flow

Abstract

Keywords

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