The structure and function of G-protein-coupled receptors

TY - JOUR

T1 - The structure and function of G-protein-coupled receptors

AU - Rosenbaum, Daniel M

AU - Rasmussen, Søren Gøgsig Faarup

AU - Kobilka, Brian K

PY - 2009/5/21

Y1 - 2009/5/21

N2 - G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

AB - G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

KW - Animals

KW - Conserved Sequence

KW - Cytoplasm

KW - Humans

KW - Opsins

KW - Protein Conformation

KW - Receptors, G-Protein-Coupled

KW - Signal Transduction

U2 - 10.1038/nature08144

DO - 10.1038/nature08144

M3 - Journal article

C2 - 19458711

SN - 0028-0836

VL - 459

SP - 356

EP - 363

JO - Nature

JF - Nature

IS - 7245

ER -