The structure and function of G-protein-coupled receptors

Daniel M Rosenbaum; Søren Gøgsig Faarup Rasmussen; Brian K Kobilka

doi:10.1038/nature08144

The structure and function of G-protein-coupled receptors

Daniel M Rosenbaum, Søren Gøgsig Faarup Rasmussen, Brian K Kobilka

Neuropharm and Genetics

1383 Citationer (Scopus)

Abstract

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

Originalsprog	Engelsk
Tidsskrift	Nature
Vol/bind	459
Udgave nummer	7245
Sider (fra-til)	356-63
Antal sider	8
ISSN	0028-0836
DOI	https://doi.org/10.1038/nature08144
Status	Udgivet - 21 maj 2009

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10.1038/nature08144

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AB - G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

KW - Animals

KW - Conserved Sequence

KW - Cytoplasm

KW - Humans

KW - Opsins

KW - Protein Conformation

KW - Receptors, G-Protein-Coupled

KW - Signal Transduction

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The structure and function of G-protein-coupled receptors

Abstract

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