The solute carrier 6 family of transporters

Stefan Bröer; Ulrik Gether

doi:10.1111/j.1476-5381.2012.01975.x

The solute carrier 6 family of transporters

119 Citations (Scopus)

Abstract

The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

Original language	English
Journal	British Journal of Pharmacology
Volume	167
Issue number	2
Pages (from-to)	256-78
Number of pages	23
DOIs	https://doi.org/10.1111/j.1476-5381.2012.01975.x
Publication status	Published - Sept 2012

Keywords

Amino Acid Sequence
Animals
Biological Transport
Gene Expression Regulation
Humans
Membrane Transport Proteins
Neurotransmitter Agents
Protein Conformation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1476-5381.2012.01975.x

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abstract = "The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.",

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AU - Gether, Ulrik

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AB - The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

KW - Amino Acid Sequence

KW - Animals

KW - Biological Transport

KW - Gene Expression Regulation

KW - Humans

KW - Membrane Transport Proteins

KW - Neurotransmitter Agents

KW - Protein Conformation

U2 - 10.1111/j.1476-5381.2012.01975.x

DO - 10.1111/j.1476-5381.2012.01975.x

M3 - Journal article

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SN - 0007-1188

VL - 167

SP - 256

EP - 278

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 2

ER -

The solute carrier 6 family of transporters

Abstract

Keywords

UN SDGs

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