The solute carrier 6 family of transporters

TY - JOUR

T1 - The solute carrier 6 family of transporters

AU - Bröer, Stefan

AU - Gether, Ulrik

N1 - © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

PY - 2012/9

Y1 - 2012/9

N2 - The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

AB - The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

KW - Amino Acid Sequence

KW - Animals

KW - Biological Transport

KW - Gene Expression Regulation

KW - Humans

KW - Membrane Transport Proteins

KW - Neurotransmitter Agents

KW - Protein Conformation

U2 - 10.1111/j.1476-5381.2012.01975.x

DO - 10.1111/j.1476-5381.2012.01975.x

M3 - Journal article

C2 - 22519513

SN - 0007-1188

VL - 167

SP - 256

EP - 278

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 2

ER -