The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

Daniel Faurholt-Jepsen; Nyagosya Range; George PrayGod; Jeremiah Kidola; Maria Faurholt-Jepsen; Martine Grosos Aabye; John Changalucha; Dirk Lund Christensen; Torben Martinussen; Henrik Bygum Krarup; Daniel Rinse Witte; Åse Bengård Andersen; Henrik Friis

doi:10.1186/1471-2334-12-165

The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

Daniel Faurholt-Jepsen, Nyagosya Range, George PrayGod, Jeremiah Kidola, Maria Faurholt-Jepsen, Martine Grosos Aabye, John Changalucha, Dirk Lund Christensen, Torben Martinussen, Henrik Bygum Krarup, Daniel Rinse Witte, Åse Bengård Andersen, Henrik Friis

Department of Immunology and Microbiology

17 Citations (Scopus)

Abstract

Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

Original language	English
Journal	B M C Infectious Diseases
Volume	12
Issue number	165
Pages (from-to)	1-8
Number of pages	8
ISSN	1471-2334
DOIs	https://doi.org/10.1186/1471-2334-12-165
Publication status	Published - 27 Jul 2012

Keywords

Adult
Body Mass Index
Cohort Studies
Diabetes Complications
Female
Hemoglobins
Humans
Male
Middle Aged
Prospective Studies
Tanzania
Treatment Outcome
Tuberculosis, Pulmonary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1471-2334-12-165

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Faurholt-Jepsen, D., Range, N., PrayGod, G., Kidola, J., Faurholt-Jepsen, M., Aabye, M. G., Changalucha, J., Christensen, D. L., Martinussen, T., Krarup, H. B., Witte, D. R., Andersen, Å. B., & Friis, H. (2012). The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania. B M C Infectious Diseases, 12(165), 1-8. https://doi.org/10.1186/1471-2334-12-165

Faurholt-Jepsen, D, Range, N, PrayGod, G, Kidola, J, Faurholt-Jepsen, M, Aabye, MG, Changalucha, J, Christensen, DL , Martinussen, T, Krarup, HB, Witte, DR, Andersen, ÅB & Friis, H 2012, 'The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania', B M C Infectious Diseases, vol. 12, no. 165, pp. 1-8. https://doi.org/10.1186/1471-2334-12-165

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title = "The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania",

abstract = "Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.",

keywords = "Adult, Body Mass Index, Cohort Studies, Diabetes Complications, Female, Hemoglobins, Humans, Male, Middle Aged, Prospective Studies, Tanzania, Treatment Outcome, Tuberculosis, Pulmonary",

author = "Daniel Faurholt-Jepsen and Nyagosya Range and George PrayGod and Jeremiah Kidola and Maria Faurholt-Jepsen and Aabye, {Martine Grosos} and John Changalucha and Christensen, {Dirk Lund} and Torben Martinussen and Krarup, {Henrik Bygum} and Witte, {Daniel Rinse} and Andersen, {{\AA}se Beng{\aa}rd} and Henrik Friis",

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doi = "10.1186/1471-2334-12-165",

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T1 - The role of diabetes co-morbidity for tuberculosis treatment outcomes

T2 - a prospective cohort study from Mwanza, Tanzania

AU - Faurholt-Jepsen, Daniel

AU - Range, Nyagosya

AU - PrayGod, George

AU - Kidola, Jeremiah

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine Grosos

AU - Changalucha, John

AU - Christensen, Dirk Lund

AU - Martinussen, Torben

AU - Krarup, Henrik Bygum

AU - Witte, Daniel Rinse

AU - Andersen, Åse Bengård

AU - Friis, Henrik

N1 - IHE 2012 058

PY - 2012/7/27

Y1 - 2012/7/27

N2 - Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

AB - Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

KW - Adult

KW - Body Mass Index

KW - Cohort Studies

KW - Diabetes Complications

KW - Female

KW - Hemoglobins

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Tanzania

KW - Treatment Outcome

KW - Tuberculosis, Pulmonary

U2 - 10.1186/1471-2334-12-165

DO - 10.1186/1471-2334-12-165

M3 - Journal article

C2 - 22839693

SN - 1471-2334

VL - 12

SP - 1

EP - 8

JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

IS - 165

ER -

The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

Abstract

Keywords

UN SDGs

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