The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

Daniel Faurholt-Jepsen; Nyagosya Range; George PrayGod; Jeremiah Kidola; Maria Faurholt-Jepsen; Martine Grosos Aabye; John Changalucha; Dirk Lund Christensen; Torben Martinussen; Henrik Bygum Krarup; Daniel Rinse Witte; Åse Bengård Andersen; Henrik Friis

doi:10.1186/1471-2334-12-165

The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

Daniel Faurholt-Jepsen, Nyagosya Range, George PrayGod, Jeremiah Kidola, Maria Faurholt-Jepsen, Martine Grosos Aabye, John Changalucha, Dirk Lund Christensen, Torben Martinussen, Henrik Bygum Krarup, Daniel Rinse Witte, Åse Bengård Andersen, Henrik Friis

LUKKET: Institut for Immunologi og Mikrobiologi

17 Citationer (Scopus)

Abstract

Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

Originalsprog	Engelsk
Tidsskrift	B M C Infectious Diseases
Vol/bind	12
Udgave nummer	165
Sider (fra-til)	1-8
Antal sider	8
ISSN	1471-2334
DOI	https://doi.org/10.1186/1471-2334-12-165
Status	Udgivet - 27 jul. 2012

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10.1186/1471-2334-12-165

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Faurholt-Jepsen, D., Range, N., PrayGod, G., Kidola, J., Faurholt-Jepsen, M., Aabye, M. G., Changalucha, J., Christensen, D. L., Martinussen, T., Krarup, H. B., Witte, D. R., Andersen, Å. B., & Friis, H. (2012). The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania. B M C Infectious Diseases, 12(165), 1-8. https://doi.org/10.1186/1471-2334-12-165

Faurholt-Jepsen, D, Range, N, PrayGod, G, Kidola, J, Faurholt-Jepsen, M, Aabye, MG, Changalucha, J, Christensen, DL , Martinussen, T, Krarup, HB, Witte, DR, Andersen, ÅB & Friis, H 2012, 'The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania', B M C Infectious Diseases, bind 12, nr. 165, s. 1-8. https://doi.org/10.1186/1471-2334-12-165

@article{6212c6880dc24aeb901ecc78ef9106c7,

title = "The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania",

abstract = "Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.",

keywords = "Adult, Body Mass Index, Cohort Studies, Diabetes Complications, Female, Hemoglobins, Humans, Male, Middle Aged, Prospective Studies, Tanzania, Treatment Outcome, Tuberculosis, Pulmonary",

author = "Daniel Faurholt-Jepsen and Nyagosya Range and George PrayGod and Jeremiah Kidola and Maria Faurholt-Jepsen and Aabye, {Martine Grosos} and John Changalucha and Christensen, {Dirk Lund} and Torben Martinussen and Krarup, {Henrik Bygum} and Witte, {Daniel Rinse} and Andersen, {{\AA}se Beng{\aa}rd} and Henrik Friis",

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doi = "10.1186/1471-2334-12-165",

language = "English",

volume = "12",

pages = "1--8",

journal = "B M C Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd.",

number = "165",

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TY - JOUR

T1 - The role of diabetes co-morbidity for tuberculosis treatment outcomes

T2 - a prospective cohort study from Mwanza, Tanzania

AU - Faurholt-Jepsen, Daniel

AU - Range, Nyagosya

AU - PrayGod, George

AU - Kidola, Jeremiah

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine Grosos

AU - Changalucha, John

AU - Christensen, Dirk Lund

AU - Martinussen, Torben

AU - Krarup, Henrik Bygum

AU - Witte, Daniel Rinse

AU - Andersen, Åse Bengård

AU - Friis, Henrik

N1 - IHE 2012 058

PY - 2012/7/27

Y1 - 2012/7/27

N2 - Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

AB - Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

KW - Adult

KW - Body Mass Index

KW - Cohort Studies

KW - Diabetes Complications

KW - Female

KW - Hemoglobins

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Tanzania

KW - Treatment Outcome

KW - Tuberculosis, Pulmonary

U2 - 10.1186/1471-2334-12-165

DO - 10.1186/1471-2334-12-165

M3 - Journal article

C2 - 22839693

SN - 1471-2334

VL - 12

SP - 1

EP - 8

JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

IS - 165

ER -

The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

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