The relationship between HbA(1c) level, symptoms and self-rated health in type 2 diabetic patients

TY - JOUR

T1 - The relationship between HbA(1c) level, symptoms and self-rated health in type 2 diabetic patients

AU - Nielsen, Anni Brit Sternhagen

AU - Gannik, Dorte Effersøe

AU - Siersma, Volkert Dirk

AU - Olivarius, Niels de Fine

PY - 2011/9

Y1 - 2011/9

N2 - Objective. Improving glycaemic control is generally supposed to reduce symptoms experienced by type 2 diabetic patients, but the relationships between glycated haemoglobin (HbA1c), diabetes-related symptoms, and self-rated health (SRH) are unclarified. This study explored the relationships between these aspects of diabetes control. Design. A cross-sectional study one year after diagnosis of type 2 diabetes. Subjects. A population-based sample of 606 type 2 diabetic patients, median age 65.6 years at diagnosis, regularly reviewed in primary care. Main outcome measures. The relationships between HbA1c, diabetes-related symptoms, and SRH. Results. The patients' median HbA1c was 7.8 (reference interval: 5.4-7.4 % at the time of the study). 270 (45.2%) reported diabetes-related symptoms within the past 14 days. SRH was associated with symptom score (γ = 0.30, p < 0.001) and HbA1c (γ = 0.17, p = 0.038) after correction for covariates. The relation between HbA1c and symptom score was explained by SRH together with other confounders, e.g. hypertension (γ = 0.02, p = 0.40). The relation between the symptom fatigue and SRH was not explained by symptom score and significantly modified the direct association between symptom score and SRH. Conclusions. Symptom relief may not occur even when HbA1c level is at its lowest average level in the natural history of diabetes, and symptoms and SRH are closely linked. Monitoring symptoms in the clinical encounter to extend information on disease severity, as measured e.g. by HbA1c, may help general practitioners and patients to understand the possible impact of treatments and of disease manifestations in order to obtain optimum disease control.

AB - Objective. Improving glycaemic control is generally supposed to reduce symptoms experienced by type 2 diabetic patients, but the relationships between glycated haemoglobin (HbA1c), diabetes-related symptoms, and self-rated health (SRH) are unclarified. This study explored the relationships between these aspects of diabetes control. Design. A cross-sectional study one year after diagnosis of type 2 diabetes. Subjects. A population-based sample of 606 type 2 diabetic patients, median age 65.6 years at diagnosis, regularly reviewed in primary care. Main outcome measures. The relationships between HbA1c, diabetes-related symptoms, and SRH. Results. The patients' median HbA1c was 7.8 (reference interval: 5.4-7.4 % at the time of the study). 270 (45.2%) reported diabetes-related symptoms within the past 14 days. SRH was associated with symptom score (γ = 0.30, p < 0.001) and HbA1c (γ = 0.17, p = 0.038) after correction for covariates. The relation between HbA1c and symptom score was explained by SRH together with other confounders, e.g. hypertension (γ = 0.02, p = 0.40). The relation between the symptom fatigue and SRH was not explained by symptom score and significantly modified the direct association between symptom score and SRH. Conclusions. Symptom relief may not occur even when HbA1c level is at its lowest average level in the natural history of diabetes, and symptoms and SRH are closely linked. Monitoring symptoms in the clinical encounter to extend information on disease severity, as measured e.g. by HbA1c, may help general practitioners and patients to understand the possible impact of treatments and of disease manifestations in order to obtain optimum disease control.

KW - care

KW - Cross-Sectional Studies

KW - Denmark

KW - diabetes

KW - diagnosis

KW - DISEASE

KW - GENERAL-PRACTICE

KW - GENERAL-PRACTITIONER

KW - general practice

KW - General Practitioners

KW - Hypertension

KW - PATIENT

KW - Patients

KW - Practice

KW - PRACTITIONERS

KW - PRIMARY-CARE

KW - Research

KW - semrap-2011-2

KW - SYMPTOMS

KW - time

M3 - Journal article

SN - 0281-3432

VL - 29

SP - 157

EP - 164

JO - Scandinavian Journal of Primary Health Care

JF - Scandinavian Journal of Primary Health Care

IS - 3

ER -