Abstract
The purpose of the present study was to determine the prognostic importance for all-cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF). Methods and results: This was a prospective prognostic study performed as part of the EchoCardiography and Heart Outcome Study (ECHOS). This analysis included 532 patients admitted with a clinical diagnosis of HF. All patients underwent spirometry and echocardiography and the diagnosis of HF was made according to established criteria. Mean forced expiratory volume in 1 s (FEV1) was 65 of the predicted value [95 confidence interval (CI) 63-67], mean forced vital capacity (FVC) was 71 of predicted (95 CI 69-72), and FEV1/FVC was 0.72 (95 CI 0.71-0.73). FEV1, FVC, and FEV1/FVC were all significant prognostic factors for all-cause mortality in univariate analyses. In a multivariate analysis, FEV1 had independent prognostic value (hazard ratio 0.86 per 10 change, P < 0.001) after adjusting for demographic variables, known risk factors, ejection fraction, and self-reported chronic obstructive pulmonary disease. Conclusion: Pulmonary function provides significant prognostic information for all-cause mortality in patients admitted with HF. Spirometry therefore seems to be worth considering for all patients admitted with HF in order to identify patients at high risk.
| Original language | English |
|---|---|
| Journal | European Journal of Heart Failure |
| Volume | 12 |
| Issue number | 7 |
| Pages (from-to) | 685-91 |
| Number of pages | 7 |
| ISSN | 1388-9842 |
| DOIs | |
| Publication status | Published - 1 Jul 2010 |
Keywords
- Aged
- Comorbidity
- Female
- Heart Failure
- Humans
- Kaplan-Meier Estimate
- Lung
- Male
- Multivariate Analysis
- Prognosis
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
- Respiratory Function Tests
- Risk Assessment
- Spirometry