TY - JOUR
T1 - The prognostic importance of lung function in patients admitted with heart failure
AU - Iversen, Kasper Karmark
AU - Kjaergaard, Jesper
AU - Akkan, Dilek
AU - Kober, Lars
AU - Torp-Pedersen, Christian
AU - Hassager, Christian
AU - Vestbo, Jorgen
AU - Kjoller, Erik
AU - ECHOS Lung Function Study Group
PY - 2010/7/1
Y1 - 2010/7/1
N2 - The purpose of the present study was to determine the prognostic importance for all-cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF). Methods and results: This was a prospective prognostic study performed as part of the EchoCardiography and Heart Outcome Study (ECHOS). This analysis included 532 patients admitted with a clinical diagnosis of HF. All patients underwent spirometry and echocardiography and the diagnosis of HF was made according to established criteria. Mean forced expiratory volume in 1 s (FEV1) was 65 of the predicted value [95 confidence interval (CI) 63-67], mean forced vital capacity (FVC) was 71 of predicted (95 CI 69-72), and FEV1/FVC was 0.72 (95 CI 0.71-0.73). FEV1, FVC, and FEV1/FVC were all significant prognostic factors for all-cause mortality in univariate analyses. In a multivariate analysis, FEV1 had independent prognostic value (hazard ratio 0.86 per 10 change, P < 0.001) after adjusting for demographic variables, known risk factors, ejection fraction, and self-reported chronic obstructive pulmonary disease. Conclusion: Pulmonary function provides significant prognostic information for all-cause mortality in patients admitted with HF. Spirometry therefore seems to be worth considering for all patients admitted with HF in order to identify patients at high risk.
AB - The purpose of the present study was to determine the prognostic importance for all-cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF). Methods and results: This was a prospective prognostic study performed as part of the EchoCardiography and Heart Outcome Study (ECHOS). This analysis included 532 patients admitted with a clinical diagnosis of HF. All patients underwent spirometry and echocardiography and the diagnosis of HF was made according to established criteria. Mean forced expiratory volume in 1 s (FEV1) was 65 of the predicted value [95 confidence interval (CI) 63-67], mean forced vital capacity (FVC) was 71 of predicted (95 CI 69-72), and FEV1/FVC was 0.72 (95 CI 0.71-0.73). FEV1, FVC, and FEV1/FVC were all significant prognostic factors for all-cause mortality in univariate analyses. In a multivariate analysis, FEV1 had independent prognostic value (hazard ratio 0.86 per 10 change, P < 0.001) after adjusting for demographic variables, known risk factors, ejection fraction, and self-reported chronic obstructive pulmonary disease. Conclusion: Pulmonary function provides significant prognostic information for all-cause mortality in patients admitted with HF. Spirometry therefore seems to be worth considering for all patients admitted with HF in order to identify patients at high risk.
KW - Aged
KW - Comorbidity
KW - Female
KW - Heart Failure
KW - Humans
KW - Kaplan-Meier Estimate
KW - Lung
KW - Male
KW - Multivariate Analysis
KW - Prognosis
KW - Prospective Studies
KW - Pulmonary Disease, Chronic Obstructive
KW - Respiratory Function Tests
KW - Risk Assessment
KW - Spirometry
U2 - 10.1093/eurjhf/hfq050
DO - 10.1093/eurjhf/hfq050
M3 - Journal article
C2 - 20395261
SN - 1567-4215
VL - 12
SP - 685
EP - 691
JO - European Journal of Heart Failure, Supplement
JF - European Journal of Heart Failure, Supplement
IS - 7
ER -