The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

Katrine Brandt Mortensen; Thomas Alexander Gerds; Ole Weis Bjerrum; Anders Lindmark; Henrik Sengeløv; Christen Lykkegaard Andersen

doi:10.1016/j.leukres.2013.12.009

The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

Katrine Brandt Mortensen, Thomas Alexander Gerds, Ole Weis Bjerrum, Anders Lindmark, Henrik Sengeløv, Christen Lykkegaard Andersen

4 Citations (Scopus)

Abstract

The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

Original language	English
Journal	Leukemia Research
Volume	38
Issue number	3
Pages (from-to)	334-9
Number of pages	6
ISSN	0145-2126
DOIs	https://doi.org/10.1016/j.leukres.2013.12.009
Publication status	Published - Mar 2014

Keywords

Adolescent
Adult
Blood Platelets
Eosinophilia
Eosinophils
Female
Glucocorticoids
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Leukemia
Male
Middle Aged
Myeloablative Agonists
Prognosis
Risk Factors
Skin
Transplantation, Homologous

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The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation. / Mortensen, Katrine Brandt; Gerds, Thomas Alexander; Bjerrum, Ole Weis et al.

In: Leukemia Research, Vol. 38, No. 3, 03.2014, p. 334-9.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation",

abstract = "The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.",

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author = "Mortensen, {Katrine Brandt} and Gerds, {Thomas Alexander} and Bjerrum, {Ole Weis} and Anders Lindmark and Henrik Sengel{\o}v and Andersen, {Christen Lykkegaard}",

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T1 - The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

AU - Mortensen, Katrine Brandt

AU - Gerds, Thomas Alexander

AU - Bjerrum, Ole Weis

AU - Lindmark, Anders

AU - Sengeløv, Henrik

AU - Andersen, Christen Lykkegaard

PY - 2014/3

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N2 - The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

AB - The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

KW - Adolescent

KW - Adult

KW - Blood Platelets

KW - Eosinophilia

KW - Eosinophils

KW - Female

KW - Glucocorticoids

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Leukemia

KW - Male

KW - Middle Aged

KW - Myeloablative Agonists

KW - Prognosis

KW - Risk Factors

KW - Skin

KW - Transplantation, Homologous

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DO - 10.1016/j.leukres.2013.12.009

M3 - Journal article

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SN - 0145-2126

VL - 38

SP - 334

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JO - Leukemia Research

JF - Leukemia Research

IS - 3

ER -

The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

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Keywords

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