The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

Katrine Brandt Mortensen; Thomas Alexander Gerds; Ole Weis Bjerrum; Anders Lindmark; Henrik Sengeløv; Christen Lykkegaard Andersen

doi:10.1016/j.leukres.2013.12.009

The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

Katrine Brandt Mortensen, Thomas Alexander Gerds, Ole Weis Bjerrum, Anders Lindmark, Henrik Sengeløv, Christen Lykkegaard Andersen

4 Citationer (Scopus)

Abstract

The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

Originalsprog	Engelsk
Tidsskrift	Leukemia Research
Vol/bind	38
Udgave nummer	3
Sider (fra-til)	334-9
Antal sider	6
ISSN	0145-2126
DOI	https://doi.org/10.1016/j.leukres.2013.12.009
Status	Udgivet - mar. 2014

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10.1016/j.leukres.2013.12.009

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@article{9cecd53ddedc4f84927028bdd5c620c4,

title = "The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation",

abstract = "The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.",

keywords = "Adolescent, Adult, Blood Platelets, Eosinophilia, Eosinophils, Female, Glucocorticoids, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Male, Middle Aged, Myeloablative Agonists, Prognosis, Risk Factors, Skin, Transplantation, Homologous",

author = "Mortensen, {Katrine Brandt} and Gerds, {Thomas Alexander} and Bjerrum, {Ole Weis} and Anders Lindmark and Henrik Sengel{\o}v and Andersen, {Christen Lykkegaard}",

year = "2014",

month = mar,

doi = "10.1016/j.leukres.2013.12.009",

language = "English",

volume = "38",

pages = "334--9",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Pergamon Press",

number = "3",

}

TY - JOUR

T1 - The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

AU - Mortensen, Katrine Brandt

AU - Gerds, Thomas Alexander

AU - Bjerrum, Ole Weis

AU - Lindmark, Anders

AU - Sengeløv, Henrik

AU - Andersen, Christen Lykkegaard

PY - 2014/3

Y1 - 2014/3

N2 - The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

AB - The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

KW - Adolescent

KW - Adult

KW - Blood Platelets

KW - Eosinophilia

KW - Eosinophils

KW - Female

KW - Glucocorticoids

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Leukemia

KW - Male

KW - Middle Aged

KW - Myeloablative Agonists

KW - Prognosis

KW - Risk Factors

KW - Skin

KW - Transplantation, Homologous

U2 - 10.1016/j.leukres.2013.12.009

DO - 10.1016/j.leukres.2013.12.009

M3 - Journal article

C2 - 24439053

SN - 0145-2126

VL - 38

SP - 334

EP - 339

JO - Leukemia Research

JF - Leukemia Research

IS - 3

ER -

The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

Abstract

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