The origin and understanding of the incretin concept

Jens F. Rehfeld

doi:10.3389/fendo.2018.00387

The origin and understanding of the incretin concept

Jens F. Rehfeld^*

^*Corresponding author for this work

Department of Clinical Medicine

21 Citations (Scopus)

25 Downloads (Pure)

Abstract

Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy. But the renewed enthusiasm has also restricted the concept to just two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). The purpose of the present overview is two-fold: First to tell that the incretin concept is far from new. It has a more than a century long history full of ups and downs. Second, that the incretin concept may now have become too narrow. Thus, it is likely that incretin comprises additional gastrointestinal hormones, which interact with GIP and GLP-1 during normal meals containing protein, fat and complex carbohydrates (and not just pure glucose). Such broader incretin concept may stimulate development of novel gut hormone-derived drugs.

Original language	English
Article number	387
Journal	Frontiers in Endocrinology
Volume	9
Issue number	JUL
Number of pages	7
ISSN	1664-2392
DOIs	https://doi.org/10.3389/fendo.2018.00387
Publication status	Published - 2018

Keywords

Gastrointestinal hormones
GIP
GLP-1
History of incretin
Incretin

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10.3389/fendo.2018.00387Licence: CC BY

The Origin and Understanding of the Incretin ConceptFinal published version, 597 KBLicence: CC BY

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AB - Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy. But the renewed enthusiasm has also restricted the concept to just two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). The purpose of the present overview is two-fold: First to tell that the incretin concept is far from new. It has a more than a century long history full of ups and downs. Second, that the incretin concept may now have become too narrow. Thus, it is likely that incretin comprises additional gastrointestinal hormones, which interact with GIP and GLP-1 during normal meals containing protein, fat and complex carbohydrates (and not just pure glucose). Such broader incretin concept may stimulate development of novel gut hormone-derived drugs.

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The origin and understanding of the incretin concept

Abstract

Keywords

UN SDGs

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